4Lu S. Immunogenicity of DNA vaccines in humans: it takes two totango [J]. Hum Vaccine, 2008 , 4(6) :449-452.
5Wolff JA, Malone RW, Williams P,et al. Direct gene transfeiB in-to mouse muscle in vivo [ J]. Science, 1990 , 247:1465-1468.
6Tang DC, Devit M, Johnston SA. 1992. Genetic immunization is asimple method for eliciting an immune response [ J]. Nature,1992,356 :152-154.
7Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protectionagainst influenza by injection of DNA encoding a viral protein [ J ]. Sci-ence, 1993,259:1745-1749.
8Klinman DM,Yi AK, Beaucage SL, et al. CpG motifs present inbacteria DNA 哪idly induce lymphocytes to secrete interleukin 6, inter-leukin 12,and interferon gamma [J]. Proc Natl Acad Sci, 1996, 93:2879-2883.
9Jones TR, Obaldia N 3rd, Gramzinski RA, et al. Synthetic oli-godeoxynucleotides containing CpG motifs enhance immunogenicity of apeptide malaria vaccine in Aotus monkeys [J], Vaccine, 1999,17(23-24) :3065-3071.
10Julie EL,Barney SG. DNA vaccines: A safe and efficient platformtechnology for responding to emerging infectious diseases [ J]. Hum Vac-cines, 2009 , 5(9):623-626.