摘要
弓形虫感染人体后，尤其是免疫低下或免疫抑制的患者，常造成严重损害。在众多疾病、尤其是自身免疫性疾病患者中，弓形虫感染率非常高，欧洲国家弓形虫抗体的阳性率在10％-80％不等，我国弓形虫抗体的阳性率在0．3％-10．0％。弓形虫感染与某些自身免疫病的发病密切相关．很多研究表明，自身免疫性疾病患者的弓形虫感染率显著高于对照组。也有动物实验证实弓形虫感染有助于保护机体，延缓疾病的进展。该文就弓形虫感染的机制和弓形虫感染与自身免疫性疾病的关系作一综述。
Toxoplasma gondii infection may cause severe damage especially in immunocompromised pateints, while the infection rate of T. gondii is high in patients with autoimmune diseases. The positive rates of T. gondii antibody are as high as 10%-80% in Europe countries while it is 0.3%-10.0% in China. There are controversial views as to the relation between autoimmune diseases and the Toxoplasma infection. In many diseases, especially in autoimmune diseases, the positive rate of anti-Toxoplasma antibody is much higher than that in other diseases or healthy controls. So it is assumed that T. gondii infection is associated closely with the pathogenesis of autoimmune diseases. However, some studies indicated that T. gondii might protect the mice against the progress of autoimmune disease or prolong the survival of mice. The mechanism of T. gondii infection and the relationship between T. gondii infection and autoimmune diseases were reviewed in this paper.
出处
《国际医学寄生虫病杂志》
CAS
2014年第6期365-368,共4页
International JOurnal of Medical Parasitic Diseases
