摘要
目的研究原发性肝细胞癌(PHcc)螺旋CT血供分型与血管内皮生长因子(VEGF)表达水平的相关性。方法对45例手术病理证实的PHcc病灶术前行螺旋CT双期扫描观察血供分型,用免疫组化SP法检测PHcc高、中、低分化者的VEGF表达水平,将两者进行对比分析。结果肝动脉供血型中VEGF表达强阳性者和阳性者均为最高,其次为肝动脉和门静脉双重供血型者。门静脉供血型和少血供型VEGF表达水平最低(P<0.001)。随着组织学分级(Edmondson-Steiner分级)的增加,VEGF表达水平增高(P<0.05)。结论螺旋CT双期扫描能够反映PHcc血供分型和血管生成情况,并能推测VEGF表达水平和组织学分级,从而有利于包括抗血管生成治疗肿瘤在内的治疗方案的选择及预后评估。
Objective To study the correlation between the blood supply types of primary hepatocellar carcinoma （PHcc） on Spiral CT and the level of vascular endothelial growth factor （VEGF） expression in PHcc for improvement in treatment strategies and prognostication. Methods Forty-five eases of PHcc identified by operation and pathology were investigated. Immunohistochemistry staining in SP was performed. The relationships between blood supply types of PHcc on Spiral CT during dual-phase scanning and the expression levels of VEGF in well-differentiated, moderately differentiated and poorly differentiated PHcc were analyzed. Results There were four blood supply types of PHcc on Spiral CT. Both the strong positive staining and the positive staining were most frequently seen in the hepatic artery blood supply type, and then were frequently in the double blood supply type, i.e. the hepatic arterial supply combining with the portal blood supply type. The positive staining results were rarely seen in the portal blood supply type and poor blood supply type （P〈0. 001）. And with the escalation of the Edmonson- Steiner histological grades, the VEGF expression levels were shown to increase correspondingly（P〈 0. 05）. Conclusion We can ascertain the blood supply type of PHcc and infer the VEGF expression levels that reflect the PHcc angiogenesis condition and the histological grades by means of Spiral CT during dual- phase scanning. Hence this method is useful for the selection of PHcc treatment plans, including anti-angiogenesis and evaluating the prognosis.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2006年第2期274-277,共4页
Journal of Sichuan University(Medical Sciences)
关键词
肝细胞癌
体层摄影术-X线计算机
血管内皮生长因子
Hepatocellular carcinoma X-ray computed tomography Vascular endothelial growth factor
