摘要
目的:研究肾衰胶囊对慢性肾衰竭(CRF)患者肾功能、肾纤维化的作用。方法:观察肾衰胶囊对慢性肾衰竭患者肾功能指标即血清肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr)和纤维化指标即血清纤维连接蛋白(FN)、透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(ColⅣ)的影响。结果:与服用尿毒清颗粒剂的对照组患者比较,肾衰胶囊有明显的降低慢性肾衰竭患者的血清Scr、BUN、HA、PC-Ⅲ、ColⅣ和提高Ccr的作用,两者比较有统计学意义(P<0.05)。结论:肾衰胶囊能改善肾纤维化,延缓慢性肾衰竭的进程。
To observe the effect of Shenshuai Capsule on renal function and renal fibrosis of patients with chronic renal failure(CRF).Methods:Effect of Shenshuai Capsule on Serum Creatinine(Scr),Blood Urea Nitrogen(BUN),Creatinine Clearance Rate(Ccr),Fibronectin(FN),Precollegen Ⅲ(PC-Ⅲ),CollagenⅣ(ColⅣ)and Hyaluronic Acid(HA)was observed in CRF patients.Results:Compared with the control values,Shenshuai Capsule significently decreased the level of Scr、BUN、HA、PC-Ⅲ、ColⅣ and elevate Ccr considerably(P<0.05).Conclusion:Shenshuai Capsule could improve renal fibrosis and delay of renal process failure.
出处
《中医药学报》
CAS
2006年第1期47-49,共3页
Acta Chinese Medicine and Pharmacology
关键词
肾衰胶囊
慢性肾衰竭
肾纤雏化
Shenshuai Capsule
Chronic Renal Failure
Renal Fibrosis
