摘要
目的 了解成纤维细胞在肾间质纤维化中的作用。方法 在原代和传代培养中,观察来自间质纤维化人肾的成纤维细胞生长及凋亡情况。结果 发现来自间质纤维化传脏的成纤维细胞分化异常,生长过度凋亡减少。结论 肾间质纤维化发病机理不仅与成纤维细胞过度生长有关,也可能与其凋亡减少有关。
Objective To study the role of fibroblasts in the pathomechanisms of renal interstitial fibrosis(RIF). Methods Growth behavior and apoptos, of renal interstitial fibroblasts in cultures, established using renal biopsies of casts with and without RIF, were studied. Results There were significant alterations in the growth behavior, the differentiation pattern of potentially mitotic fibroblast populations and programmed cell death in cultures derived from kidneys with RIF, as compared with cultures of normal origin. Conclusion The abnormal growth and apoptosis of fibroblasts may play an im-portant role in RIF. Inhibiting the proliferation and promoting the programmed death of fibroblasts may be benificial to patients with RIF.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1997年第2期76-78,共3页
Chinese Journal of Nephrology
