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精子发生基因表达的调控研究进展 被引量：4

Progress on regulation studies of gene expression during spermiogenesis
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摘要 在精子发生的不同阶段,睾丸组织特异性基因的按严格的时间、空间特性表达,这些基因在不同的调节因子作用下从多个层次对精子发生过程进行调控,最终形成成熟的精子。本文对生精细胞及非生精细胞中睾丸特异性基因的表达及其调控进行了综述。 Testis-specific genes display a temporal and spatial pattern of expression at different stages of spermiogenesis. Many transcription factors are required for the regulation of these testis-specific genes, In this article we describe some of the testis-specific genes that are expressed and regulated in male germinal cells and in non-germinal testis cells.
作者 余振东 桂耀庭 唐爱发 蔡志明
机构地区 北京大学深圳医院
出处 《中国实验诊断学》 2006年第1期104-107,共4页 Chinese Journal of Laboratory Diagnosis
基金 国家自然科学基金资助项目(30471728)
关键词 精子发生 睾丸 基因表达 转录调控 spermiogcnesis testis gene expression transcriptional control
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献19

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同被引文献36

  • 1姚兵,张蕾蕾,崔英霞,王咏梅,黄宇烽.睾丸生精障碍患者血清抗FSH抗体的测定及临床意义[J].中华男科学杂志,2004,10(7):491-492. 被引量：4
  • 2Zhang Z, Sapiro R, Kapfhamer D, et al. A sperm-associated WD repeat protein orthologous to chlamydomonas PF20 associates with Spag6, the mammalian orthologue of chlamydomonas PF16. Mol Cell Biol, 2002, 22(22) : 7993-8004.
  • 3Zhang Z, Kostetskii I, Moss SB, et al. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogen- esis. Prec Nail Acad Sci USA, 2004, 101(35) : 12946-12951.
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  • 5Zhang Z, Shen X, Jones BH, et al. Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis- specific kinase, TSSK2. Biol Reprod, 2008, 79( 1 ) : 75-83.
  • 6McClintock TS, Glasser CE, Bose SC, et al. Tissue expression patterns identify mousecilia genes. Physiol Genomics, 2008, 32 (2) : 198-206.
  • 7Lesich KA, Zhang Z, Kelsch CB, et al. Functional deficiencies and a reduced response to calcium in the flagellum of mouse sperm lacking SPAG16L. Biol Reprod, 2010, 82(4) : 736-744.
  • 8Marshall WF. Basal bodies platforms for building cilia. Curt Top Dev Biol, 2008, 85 ( 1 ) : 1-22.
  • 9Mazor M, Alkrinawi S, Chalifa-Caspi V, et al. Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1. Am J Hum Genet, 2011, 88 ( 5 ) : 599- 607.
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中国实验诊断学
2006年 第1期

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