摘要
肝脏和胰腺前体细胞都是由胚胎前肠内胚层细胞发育而来的。脊椎动物中,在高度保守的诱导信号和遗传调节因子作用下,肝脏和胰腺前体细胞特化,并获得器官功能和再生能力。由于对肝脏疾病和Ⅰ型糖尿病有重要的临床价值,肝脏、胰腺的发育和再生机制成为了研究热点。通过对不同模式生物的研究,揭示了进化上保守的诱导信号和转录因子诱导肝脏、胰腺细胞的分化机制,这为干细胞和前体细胞如何诱导分化为肝实质细胞和胰腺β细胞提供了理论依据。
Liver and pancreas progenitors all develop from endoderm cells in the embryonic foregut. Shortly after their specification, liver and pancreas progenitors rapidly acquire markedly different cellular functions and regenerative capacities, and these changes are elicited by inductive signals and genetic regulatory factors that are highly conserved among vertebrates. Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic β-cells in the therapeutic treatment of liver failure and type Ⅰ diabetes. Studies in diverse model organisms have revealed evolutionarily conserved inductive signals and transcription factor networks that elicit the differentiation of liver and pancreatic cells and provide guidance for how to promote hepatocyte and β-cell differentiation from diverse stem and progenitor cell types.
出处
《畜牧与饲料科学》
2012年第2期67-69,共3页
Animal Husbandry and Feed Science
关键词
肝脏细胞
胰腺细胞
发育
再生
liver cells
pancreatic cells
growth
regeneration
