摘要
目的探讨胃癌患者循环血管内皮生长因子(VEGF)和白细胞介素-8(IL-8)水平的变化及其与胃癌临床病理学特征的关系。方法应用酶联免疫吸附法(ELISA)测定47例胃癌患者循环血浆VEGF、IL-8浓度,结合临床病理学资料进行分析。结果胃癌患者循环血浆VEGF浓度为(65.12±29.53)pg/ml,显著高于正常对照组(32.97±9.79)pg/ml(P<0.01);IL-8浓度为(3.01±0.68)pg/ml,与对照组比较,差异无显著性意义(P>0.05)。肿瘤浸润深度超过肌层,伴有淋巴结转移、血管浸润者,其循环血浆VEGF明显升高(P<0.05或P<0.01)。循环血浆VEGF、IL-8之间呈弱正相关(r=0.433)。结论循环血浆VEGF水平与胃癌浸润、转移等有关。循环VEGF、IL-8之间有一定的相关性,联合检测循环血浆VEGF、IL-8对胃癌的诊断、疗效判断等有一定的价值。
Objective To explore the changes of plasma VEGF,IL - 8 and relationship between them and clinicopathological characters in gastric cancer patients. Methods 47 cases of gastric carcinoma and 20 normal control＇ s plasma samples were measured by Enzyme - Linked Immunosorbent Assay （ELISA）. Results The plasma level of VEGF and IL - 8 in gastric carcinoma patients were （ 65.12 ± 29.53 ） pg/ml and （ 3.01 ± 0.68 ） pg/ml respectively, and VEGF was significantly higher than healthy control＇ s（ P 〈 0.01 ）. VEGF concentration was higher in patients with lymph node metastasis, deeply invasion ,venous invasion, and IL - 8 was higher in venous invasion of gastric carcinoma. A mild correlation between VEGF level and IL - 8 was found. Conclusion The VEGF and IL - 8 are association with tumor progresses. Measurement of plasma VEGF and IL - 8 might be useful for diagnosis as biomarkers, and provided a predictor for invasion, metastasis and prognosis. VEGF and IL- 8 might play a important role of evolution in gastric carcinoma.
出处
《浙江临床医学》
2005年第12期1241-1242,共2页
Zhejiang Clinical Medical Journal
