摘要
目的:观察缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)新生儿血浆中血管内皮生长因子(vascular endothelialgrowth factor,VEGF)含量的动态变化,探讨VEGF与HIE发病机制及早期诊断的临床相关性。方法:选择90例确诊为HIE的足月新生儿作为观察组(HIE组),酶联免疫吸附试验分别测定出生后第1天、第3天(急性期)和第7天(恢复期)血浆VEGF;同时测定30例无神经系统疾病的足月新生儿(对照组)出生后第1天、第3天、第7天的血浆VEGF。结果:HIE组患儿血浆VEGF在出生后第1天、第3天和第7天均显著升高,与对照组差异有统计学意义(P<0.01);第1天达高峰,以后下降,与第7天比较,差异有统计学意义(P<0.01)。结论:VEGF变化对判断有无HIE有重要意义。
Objective： To observe the dynamic changes of vascular endothelial growth factor （VEGF）in the blood plasma of the newborns with hypoxic ischemic encephalopathy （ HIE）, and to investigate the correlation of VEGF with the pathogenesis and early diagnosis of HIE. Methods：Ninety full-term newborns with HIE were chosen as the experimental group, and the VEGF in plasma was examined on the 1 st day, the 3rd day （acute stage）and the 7th day （the recovery stage）after birth using enzyme linked immunosorbent assay（ELISA） ;30 neonates with no nervous system diseases acted as control. Results：VEGF in the experimental group on the 1 st day, 3rd day and 7th day after birth increased significantly compared with that in the control（ P 〈 0.01 ）, and it reached the peak on the 1st day,and then descended. The VEGF on the first day was much higher than that on the 7th day（P 〈 0.01 ）. Conclusions：VEGF can be used as a significant index in diagnosis of HIE.
出处
《蚌埠医学院学报》
CAS
2009年第8期669-671,共3页
Journal of Bengbu Medical College
基金
安徽省教育厅自然科学研究资助项目(2006kj108C)
关键词
婴儿
新生
疾病
脑缺氧
脑缺血
血管内皮生长因子
infant, newborn, diseases
cerebral anoxia
cerebral ischemia
vascular endothelial growth factor
