摘要
对25例原发性高血压（EH）患者，采用酶联免疫吸附法测定血浆中反映血管内皮细胞（vEC）损伤的指标──第Ⅷ因子相关抗原（vWF），硫代巴比妥酸法测定血浆中反映氧自由基损伤水平的脂质过氧化物（LPO）。结果发现，EH患者血浆vWF和LPO浓度均显著高于正常对照组（P＜0．05），且LPO与vWF浓度呈显著的正相关（P＜0．05）。提示EH患者存在有VEC损伤，氧自由基是导致VEC损伤的重要因素之一。
25 cases ill with essential hepertension (EH) were studied using enzyme linked immunosorbent assay (ELISA) to determine the index reflecting the damage of vascular endotheliocytes (VEC) in the plasma-factor Ⅷ related antigen and using thiobarbituric acid as say to determiine lipid peroxide reflecting the damage level of oxygen free radical in the plasme. The results showed that the concentrations of both the fartor Ⅷ related antigen and the lipid peroxide in the plasma of the patients ill with essential hepertension were significantly higher than those in normal control group(P<0. 05) and there was significantly positive correlation between the factor Ⅷ related antigen and the lipid peroxide (P<0. 05). The data mentioned above indicate that there is the damage of vascular endotheliocytes in the patients ill with essential hypertension and one of the important factors that leads to the damage of vascular endotheliocytes is oxygen free redical.
出处
《洛阳医专学报》
1996年第1期26-28,共3页
Journal of Luoyang Medical College
关键词
原发性
高血压
第Ⅷ因子
相关抗原
过氧化脂质
essential hypertension
factor Ⅷ related antigen
lipid peroxide
vascular endotheliocyte
