摘要
目的:检测冠心病(CHD)患者血中炎症标志物及脂质过氧化物浓度并探讨其在CHD病变过程中作用及相互关系。方法:用散射比浊法、酶联免疫法及比色分析法分别测定CHD患者及CHD所致充血性心力衰竭(CHF)患者血中C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和氧化型低密度脂蛋白(OX-LDL)、丙二醛(MDA)的浓度并与健康对照比较。结果:CHD患者组血浆CRP、IL-6、TNF-α、OX-LDL及MDA浓度明显高于对照组(P<0.01),发生CHF后,其浓度进一步升高(P<0.05,P<0.01);相关分析表明:CRP与IL-6、TNF-α之间呈正相关(r=0.08,0.69;P<0.05);OX-LDL与MDA、CRP、IL-6 ;TNF-α之间呈正相关(r=0.63,0.78,0.62,0.55;P<0.05),MDA与CRP、IL-6、TNF-α之间也呈正相关(r=0.73,0.60,0.54;P<0.05)。结论:炎症反应与脂质代谢紊乱在CHD的病变过程中起着关键作用,两种因素相互作用、相互影响,导致CHD的发生与发展。
Objective:To measure the concentration of inflammatory markers and lipid peroxide in patients with coronary heart dis-ease(CHD) and explore its internal relationship.Methods: Use nephelometer measure, enzyme linked immunosorbent assay(ELISA) and colorimetry methods, we detected the concentration of C-reactive protein( CRP) , interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α),oxidized low density Iipoprotein(OX-LDL)and malondialdehyde(CHF) and compared with 30 healthy controls. Results:The plasma CRP, IL-6, TNF-α, OX-LDL and MDA levels in CHD were markedly higher than normal controls( P < 0.01), and the concentration of Inflammatory markers and lipid peroxide increased with developing of CHF. The analysis of linear correktion showed the levels of CRP positively correlated with the IL6,TNF-α( r = 0.81,0.69, P < 0.05) ;OX-LDL positively correlated with the MDA,CRP, IL-6,and TNF-α( r = 0.63,0.76,0.62,0.55, P < 0.05), MDA also positively correlated with CRP.IL6 and TNF-α( r = 0.73, 0.60,0.54, P<0.05). Conclusion:Inflammation was closely associated with lipid metabolism disorder,They may play an important role in development of CHD.
出处
《医学理论与实践》
2003年第6期626-628,共3页
The Journal of Medical Theory and Practice
