摘要
目的 探讨飞行人员血尿酸与心血管危险因素的关系.方法 对象为606例男性飞行人员,测量身高、体重、血压、胸围、腰围及臀围;实验室检测血尿酸、血脂、血糖、尿素、肌酐及生化参数,并进行包括生活习惯、个人及家族疾病史、飞行负荷的问卷调查.将血尿酸水平分为4层:≤298、299～357、358～417、＞417 μmol/L,最后1层为临床诊断高尿酸血症标准.以血尿酸为自变量,其他多种心血管危险因素为因变量,分析血尿酸与这些危险因素的关系.结果 飞行人员高尿酸血症患病率16.67%.血尿酸与临床化学标志物TG、TC、载脂蛋白A1、载脂蛋白B、空腹血糖、肌酐、总蛋白、γ-转肽酶、碱性磷酸酶、总胆汁酸、乳酸脱氢酶和丙氨酸转氨酶呈正相关(r=0.65、0.24、0.22、0.42、0.29、0.11、0.33、0.25、0.17、0.17、0.11、0.10),临床化学标志物均值随血尿酸水平升高而增高;与年龄、BMI、胸围、腰围、臀围及收缩压呈正相关(r=0.11、0.24、0.19、0.19、0.17、0.14),生理参数均值亦随血尿酸水平升高而增高.吸烟量≥20支/d者高PUA血症患病率高于吸烟量＜20支/d者(x2=13.14,P＜0.01).有心脑血管病家族史者高PUA血症患病率高于其他人员(x2=9.506,P＜0.01).多元回归和Logistic回归分析显示血尿酸水平与TG和肌酐水平独立相关.结论 高尿酸和高TG血症是动脉粥样硬化形成和发展的独立危险因素;与血尿酸相关的载脂蛋白B,空腹血糖升高,收缩压升高,体质指数、胸围、腰围和臀围超标,吸烟量大和相关家族史构成心血管疾病的综合危险因素.
Objective To investigate the relationship between plasma uric acid (PUA) level and cardiovascular risk factors for Chinese military flying personnel. Methods Six hundred and six flying personnel served as subjects and their blood pressure, height, weight, chest circumference (CC), waist circumference (WC), hip circumference (HC) were measured. PUA, blood fat, blood glucose, carbonylamines, creatinine and other biochemical indicators were tested. The information,such as living habit, personal and family disease history, as well as workload in flight was got by questionnaire. PUA level was divided into four classes: ≤298, 299-357, 358-417 and ＞417μmol/L. The last one was taken as the clinical diagnostic standard for hyperuricemia. The relationship between PUA level and chosen risk factors was analyzed by one-way ANOVA, Chi-square or t-test and multiple regression or binary logistic regression. Results The incidence of hyperuricemia was 16. 67% in Chinese military flying personnel. PUA levels were positively correlated with clinical biochemical parameters: TG, TC, apolipoprotein A1 (ApoA1), apolipoprotein 13 (ApoB), fasting blood glucose (FBG), creatinine, total protein, gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bile acid (TBA), lactate dehydrogenase (LDH) and ALT(r=0.65, 0.24,0.22, 0.42, 0.29, 0.11, 0,33, 0.25, 0.17, 0.17, 0.11, 0.10 respectively). The mean values of these clinical biochemical flag parameters, corresponding to different PUA classes, were gradually increased with PUA level raise. PUA level was positively correlated with age, body mass index (BMI), CC, WC, HC, and systolic blood pressure (SBP) (r=0. 11, 0.24, 0. 19, 0. 19, 0. 17, 0. 14 respectively). The incidence of hyperuricemia is higher in the group of smoking cigarette ≥ 20 bars/day (x2 = 13.14, P＜0.01 ) and in the group with family cardiovascular disease history (x2 =9. 506, P＜0. 01). Multiple regression and binary Logistic regression analysis revealed that the relationship of PUA concentration with triglyceride and creatinine was independently correlated. Conclusions Hyperuricemia and hypertriglyceridemia were the independent risk factors of causing and driving arteriosclerosis. Other PUA related ingredients, such as high ApoB, high FBG, high SBG, super CC,WC and HC, over weight, smoking habit and family disease history are composed of multiple risk factors of resulting in cardiovascular diseases.
出处
《中华航空航天医学杂志》
CSCD
2010年第2期134-141,共8页
Chinese Journal of Aerospace Medicine
关键词
高尿酸血症
尿酸
心血管疾病
危险因素
代谢
体重与身体测量
Hyperuricemia
Uric acid
Cardiovascular diseases
Risk factors
Metabolism
Body weights and measures
