摘要
用心输出量计算机测定烧伤休克大鼠心血管功能,发现早在烧伤后10分钟心输出量已减少40%,心室功减少47%,全身外周阻力升高50%。伤后2小时由于外周阻力代偿性升高2.6倍,使血压仍能维持正常。随病程进展,心输出量进一步减低,全身外周阻力开始下降,动物进入失代偿阶段。注射虎杖4号使烧伤后下降的心输出量恢复至伤前的91%,心室功达100.1%,全身外周阻力恢复到接近正常,动物存活率明显提高。
A burn shock model was produced in rats by scalding the lumbus and lower extremities with 80℃ water for 30 seconds. The variable of cardiac functions were measured with a Cardiac-II-R cardio-output computer. It was shown that heart functions decreased as early as 10 min following scalding. Cardiac output (CO), cardiac index (CI), and stroke volume index (SVI) were reduced by 40% of normal. and stroke work (SW) by 47%. With the decrease of CO, total peripheral resistance (TPR) increased. Two hour later TPR was increased 2.6-fold more than pre-burn level, which made BP maintain nearly normal. TPR started to reduce at 3 hr post-burn, resulting in decrease of BP. The decreased heart func- tion returned to near normal by administration of crystal of Polygonum cuspidatum No 4 (p.c). e.g, CO and CI were increased to 91.0% of pre-burn value, SW to 100.1%, and SVI to 102.0%. The increased TPR was reduced to near normal. Half of p. c.-treated ani- mals survived within 24 hr, but all of simple burn animals and n. s.-treated animals died within 24 hr. Under the condition of no fluid infusion, administration of p .c. could re- store the decreased heart function, which showed that besides loss of plasma, direct myocar- dial depression was one of the reason for the decrease of cardiac output during burn shock. The survival rate of animals with burn shock was enhanced by injection of p .c., which indicated that increasing heart function was a very important measure for the treatment of burn shock.
基金
国家自然科学基金
