摘要
为了寻找内毒素休克时损伤器官的保护方法，达到延缓和减轻器官损伤的目的，我们复制了大鼠内毒素休克模型，应用白藜芦醇甙处理，以探讨其对大鼠内毒素休克时损伤器官的保护作用。实验结果：白藜芦醇甙处理组大鼠的肝、肾、肺、肠组织的肿瘤坏死因子、丙二醛明显低于休克对照组（Ｐ＜０．０１）；而超氧化物歧化酶则明显高于休克对照组（Ｐ＜０．０１）；并且白黎芦醇甙处理组大鼠的肝、肾功能状态好于休克对照组，其肺灌洗液蛋白低于休克对照组（Ｐ＜０．０１）。说明，白藜芦醇甙对内毒素休克大鼠的损伤器官具有保护作用。
In order to explore the
protective method to delayand reduce organ injury,we made the endotoxic shockmodel in
rats,and studied the protective effect of poly-datin on multiple organ injury in rats with
endotoxicshock.The results showed that the concentrations of tu-mor necrosis
factor(TNF),superoxide dismutase(SOD)and malon aldehyde(MDA)in the liver , kidney,lung
andintestine in rats treated with polydatin were significantlylower than those in the shock control
group (P<0.01 )。However. the concentration of SOD was higher in theformer group than that in
the latter group (P < 0.01). The liver and kidney functions in polydatin treated groupwere better
than shock control group(P<0.01),and theprotein level of BALF was lower than shock
controlgroup(P<0.01 ).It is indicated that polydatin plays aprotective role on organ injury in rats
with endotoxicshock.
出处
《中国危重病急救医学》
CAS
CSCD
1995年第6期352-354,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金
