摘要
目的:探讨2型糖尿病患者血浆白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子(TNF-α)在糖尿病发生、发展过程中的浓度变化及相互关系。方法:用放射免疫分析检测45例2型糖尿病患者及33例年龄和性别相匹配的健康志愿者血清IL-6、IL-8、TNF-α的水平。结果:①2型糖尿病患者血中IL-6、IL-8、TNF-α水平明显高于对照组(P<0.01);②有合并症患者血清IL-8、TNF-α水平明显高于单纯糖尿病患者(P<0.02);③三种细胞因子间浓度呈正相关(P<0.01)。结论:细胞因子IL-6、IL-8、TNF-α在糖尿病的发生、发展过程中相互作用,观察其浓度变化对探讨糖尿病的发病机理、预防及指导用药均有重要价值。
Objective To investigate the role played by serum cytokines （ IL - 6, IL - 8, TNF-α） in the pathogenesis of diabetes mellitus. Methods Serum IL - 6, IL - 8 and TNF-α levels were measured with RIA in 27 diabetic patients without complications, 18 patients with early nephro or retinopathy and 33 controls. Results ①Serum levels of IL - 6, IL - 8 and TNF-α were significantly higher in the diabetic patients than those in controls （ P 〈 0.01 ）. ②Levles of the cytokines in diabetic patients with early complications were significantly higher than those in patients without complications （ P 〈 0.02 ）.③The serum levels of these cytokines were mutually positively correlated. Conclusion The cytokines IL - 6, IL - 8 and TNF -α participated in the development and patho - physiology of diabetes mellitus and monitoring their plasma level changes would be clinically useful.
出处
《放射免疫学杂志》
CAS
2005年第4期267-269,共3页
Journal of Radioimmanology
