摘要
目的:探讨2型糖尿病患者治疗前后血浆内皮素(ET)和血清肿瘤坏死因子(TNF-α)水平的变化及临床意义。方法:应用放射免疫分析检测54例糖尿病患者血浆ET和血清TNF-α水平,并与35例正常健康人作比较。结果:2型糖尿病患者在治疗前血浆ET、血清TNF-α水平显著地高于正常人组(P<0.01),经治疗3个月后,与正常人比较仍有显著性差异(P<0.05)。结论:2型糖尿病的发生、发展与ET、TNF-α水平密切相关。
Objective To investigate the clinical significance of the changes of plasma ET and serum TNF levels after treatment in patients with diabetes millitus. Methods Plasma ET and serum TNF contents were determined with RIA in 54 patients with diabetes mellitus both before and after treatment as well as in 35 controls. Results Before treatment, the plasma ET and serum TNF levels were significantly in the diabetics higher than those in the controls （P 〈0.01 ）. After 3months treatment, the levels remained significantly higher （P 〈 0.05）. Conclusion Development and progression of diabetes millitus were closely related to the plasma ET and serum TNF levels.
出处
《放射免疫学杂志》
CAS
2006年第4期308-309,共2页
Journal of Radioimmanology
关键词
2型糖尿病
内皮素
肿瘤坏死因子
diabetes millitus, endothelin （ET）, tumor necrosis factor （TNF）
