摘要
探索山东地区丙型肝炎病毒(HCV)的基因型及血清学分型的分布,了解HCV基因型与感染途径的关系。对96例抗HCV阳性患者的血清进行HCV RNA检测,HCV RNA阳性者,应用限制性片段长度多态性分析(RELP)进行基因分型;同时应用Murex Serotyping HCV 1-6血清学分型试剂进行血清学分型。基因非2(1b)型79 例,占83.16%,2(2a)型为16例占16.84%,44份血清标本的血清学分型可分型率为90.91%,与基因分型的符合率为90.00%。不同的感染途径之间,基因型分布没有差异(P=0.15)。山东地区丙型肝炎病毒流行株为基因非2 (1b)和2(2a)型,非2(1b)型为优势株,基因分型与血清学分型结果基本一致,基因型与丙型肝炎的感染途径无关。
To study the distribution of genotypes and serotyppes of HCV in Shandong province and to know the relation between HCV genotypes and the ways to infect HCV. 96 serum samples of patients infected with HCV were tested genotype by using RFLP assay and 44 of 96 serum samples were examined serotypes with Murex Serotyping HCV 1 - 6 reagent. There were no differences among different groups classifed by the way to infected HCV. 95 patients out of the total 96 were positive for HCV RNA. 79 of them （83.16%） were infected with HCV genotype none 2 （1b） while the other 16 （ 16.84% ） had HCV genotype 2 （2a） .The prevalent HCV strains in Shandong province were genotype 1b and 2a with 1 b dominating. The genotypes of patients infected with HCV accorded with serotypes. There was no relation between HCV genotypes and the ways to infect HCV.
出处
《临床肝胆病杂志》
CAS
2005年第4期215-216,共2页
Journal of Clinical Hepatology
