摘要
目的探讨在血清肌酐正常的老年肾损害患者中,胱抑素(cystatin C,Cys-C)对肾小球滤过率(GFR)评价的意义.方法对2002-11～2003-12泸州医学院附属医院86例有肾损害但血清肌酐(Scr)正常的老年患者,应用乳胶颗粒增强比浊法测定血清中Cys-C浓度,并采用CockCroft-Cault公式计算内生肌酐清除率(Ccr).分别比较Cys-C与Scr和Ccr的相关性.结果 56例Cys-C升高超过正常,占56.1%;比较Ccr≤59 mL/min和Ccr>59 mL/min两组间的Cys-C质量浓度发现,当Ccr≤50 mL/min时,97.1%的患者Cys-C超过正常,在Ccr>59 mL/min时,已有44.2%患者Cys-C超过正常.血清Cys-C与Scr存在高度的正直线相关(r=0.89,P<0.01);Cys-C与Ccr存在高度的负直线相关(r=-0.87,P<0.01).结论在老年患者中,Cys-C比Scr和Ccr更敏感地反映早期肾小球滤过率的下降.
Objective To explore the relationship bewteen serum cystatin C （Cys- C ） and glomemlar filtration rate （GFR） in creatinine- blind range elderly patients. Methods From Jan. 2002 to Dec. 2003, in the Affiliated Hospital of Luzhou Medical College, the study was performed in 86 elderly patients with chronic renal disease. Serum Cys-C was determined by particle - enhanced immunoturbidimetry. Serum creatinine （Ser） was determined by auto - analyzer. Creatinine clearance rate （Ccr） was estimated by CockCroft - Cault formula. For statistical evaluation, linear regression analysis was used. Results Concentration of Cys - C increased in 56 patients （56.1% ）. When Ccr was higher than 59mL/min, concentration of Cys- C increased in 44.2% patients. Significant positive correlation was observed between Cys-C and Ser （ r =0.89, P〈0.01）. Cys- C was negatively correlated with Ccr （ r = -0.87，P〈0.01）. Conclusion Cys- C is a more sensitive parameter than Ser and Ccr for early stage reduced GFR.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第8期725-726,共2页
Chinese Journal of Practical Internal Medicine
