摘要
目的探讨几种常见肾功能指标对评估慢性肾病患者肾脏病理变化的价值。方法选择2003年11月至2004年11月在苏州大学附属第二医院肾内科住院的54例慢性肾病患者,用RXL生化分析仪测定血肌酐(Scr)并通过MDRD方程计算肾小球滤过率(GFR)。检测血清胱蛋白酶抑制剂(CysC)、β2微球蛋白(β2-MG),以24h尿蛋白定量及蛋白尿持续时间的乘积计算尿蛋白指数,根据肾穿刺检查病理结果衡量肾小球指数和肾间质病变程度判定疾病进展情况。结果慢性肾病患者的血清CysC、Scr、血β2-MG、蛋白尿指数、GFR与肾脏病理变化程度相关。其中GFR和血清CysC与肾脏病理进展程度高度相关。结论在慢性肾病进展评估中应该同时考虑CysC及蛋白尿指数,能更全面地反映慢性肾脏疾病的进展情况。
Objective To assess the value of serum creatinine （ Scr）, serum β2-micmglobulin （β2-MG）, glomerular illtration rate（ GFR）, pmteinuria index, and Cystatin C （Cys C ）to detect impairing of expressing of diease in patients with chronic kidney disease. Methods Peripheral blood was collected from 54 chronic kidney diease：Scr was analyzed using RXL fully automated biochemistry assay instrument, then GFR was calculated ; Cys C was measured using particle-enhanced nephelometric immunoassay （PENIA） ; β2-MG was measured using chemiluminescent method, pmteinuria index was measured by the product of duration and amount of pmteinuria, nephropathological progress was measured using the degree of glomerular mesangial proliferation and the dgree of tubulointerstitial fibrosis. Results The level of serum Cys C, Scr, serum β2-MG, pmteinuria index,and GFR of the CKD patients was correlated with nephropathological progressing. Conclusion In patients with chronic kidney disease serum creatinine, serum β2-micm-globulin, glomerular filtration rate,pmteinuria index,and Cystatin C are markers of progessing of kidney disease. The sensitivity and correlation of GFR and serum Cys C are. higher than others.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第3期213-214,共2页
Chinese Journal of Practical Internal Medicine
