摘要
对９２例各型乙肝患者红细胞超氧化物歧化酶（ＣＲＣ－ＳＯＤ）、血浆过氧化酯质（ＬＰＯ）及红细胞免疫粘附功能检测发现，除急性乙型肝炎外，其它各型乙肝患者ＲＢＣ－ＳＯＤ明显下降，血浆ＬＰＯ明显升高，红细胞Ｃ３ｂ受体（ＲＢＣＣ３ｂＲ）明显减少或功能有明显抑制，红细胞免疫复合物花环（ＲＢＣ－ＩＣＲ）亦有明显降低。ＲＢＣＣ３ｂＲ减少与血中ＬＰＯ浓度成负相关。推测各类乙肝患者由于其ＲＢＣ－ＳＯＤ活性下降导致血中ＬＰＯ浓度升高，并因此而损伤红细胞免疫功能粘附功能，红细胞对循环免疫复合物清除能力降低并进一步造成肝细胞损伤。本研究有助于进一步揭示乙肝发病机理，对临床判断病情疗效等也有一定帮助。
RBC-SOD activity , serum LPO concentration and RBC immunoad herence abllitywere measured in 35 health adults and 92 patients with viral hepatitis B,including acute hepatitisB(AHB),chronic persistent hepatitis B, chronic active hepatitis B,hepatitis B gravis and posthepatitis cirrhosis. It was shown that the concentration of serum LPO increased while the RBC-SOD activity deCreased in all types of patients except AHB group, compared with the control group.RBC-C3bR and RBC-ICR in the patients group decreased as well(p<0. 05 or 0. 01).The levels of RBC-C3bR was negatively related to serum LPO in the patients(r=-0. 87 and-0.92).These results suggest that the lowered RBC-SOD activity may,bring about high level of serum LPO which damage the RBC immuanodherence capacity and lead to hepatocyte necrosis progressivly.
出处
《广东药学院学报》
CAS
1995年第4期250-252,共3页
Academic Journal of Guangdong College of Pharmacy
