摘要
采用捕捉法ELISA检测HBsAg无症状携带者、急性肝炎,慢性迁延型肝炎,慢性话动性肝炎、重型肝炎和肝炎后肝硬化患者的血清,共275例。发现其中120例为血清IgA特异性激活补体类免疫复合物(IgA/C_3-CIC)高于健康人的阳性病例,阳性率依次为9.8％、36.4％、35.2％、58.2％、72.2％和61.5％,相互间差异非常显著(P<0.01)。经Cochran-Armira-ge趋势分析证明,阳性率随肝损害程度加重而上升,差异非常显著(P<0.01)。阳性率在慢性活动性肝炎中还与谷丙转氨酶密切相关。这些结果说明,IgA/C_3-CIC的存在与乙型肝炎临床病型有关,可作为乙型肝炎临床鉴别诊断的一个辅助指标;其阳性率与乙型肝炎肝损害之间存在互为因果的关系,这种关系在不同临床类型乙型肝炎中的表现形式不同,以慢性活动性肝炎最为明显。IgA/C_3-CIC在乙型肝炎中的病理作用不容忽视。
By an complement capture-ELISA method,amounts of circulating IgA specific immune complexes activating complement (IgA/C3-CIC)were exa-mined in different clinical types of hepatitis B infection. The positive rates of IgA/C3-CIC in HBsAg asymptomatic carriers, acute hepaitis B, chronic persistent hepatitis B, chronic active hepatitis B,severe hepatitis B and cirrhosis after hepatitis B were 9.8%, 36.4%, 35.2%,58.2%, 72.2% and 61.5% respectively,showing statistically significant differences between the groups. The positive rates of IgA/C3-CIC were positively related with the degree of liver damage in different types of hepatitis B by Cochran-Armitage's tendency analysis and in chronic active hepatitis B, were sig nificantly higher in the increased ALT group than in the normai ALT group. These results suggest that a cause-effect relationship may exist bet-ween the positive rate of IgA/C3-CIC and liver damage of chronic active hepatitis B. It is concluded that IgA/C3-CIC may be one of the valuable markers in distinguishing different clinical types of hepatitis B from each other, and its pathogenic significance of IgA/C3-CIC should be consi-dered.
出处
《病毒学报》
CAS
CSCD
北大核心
1993年第4期325-330,共6页
Chinese Journal of Virology
基金
江西省自然科学基金
关键词
乙型肝炎
免疫复合物
免疫球蛋白A
Hepatitis B, Circulating immune complexes,Immunoglobu-lin A, Complement, ELISA
