摘要
本文报道用捕捉法ELISA检测各型乙肝IgA型HBsAg循环免疫复合物。结果表明,慢性乙肝IgA型HBsAg循环免疫复合物检出率显著高于急性乙肝;在慢性乙肝中,IgA型HBsAg循环免疫复合物的出现与HBVe系统关系密切,主要存在于HBeAg阳性血清中,并与HBeAg滴度有关。故IgA型HBsAg循环免疫复合物可作为HBV慢性感染的血清诊断标志之一;也可作为反映HBV在增殖并有传播危险的标志之一。
Circulating HBsAg/IgA immune complexes were detected in different groups of hepatitis B patiens by ACCA-ELISA(antibody class capture assay ELISA). The positive rates of chronic hepatitis B were significantly higher than those of acute hepatitis B, The occuranceof circulating HBsAg/IgA immune complexes was closely associated with HBV e system and the titer of HBeAg. These results seem to indicate that the immune response to form circulating HBsAg/IgA immune complexes may be a valuable marker of chronic infection of HBV; and it may also be considered as a marker of replication of HBV.
