摘要
舒普深（ＳＬＰ）是一种β－内本义酶抑制剂青霉烷砜与头孢哌酮（ＣＦＰ）配伍组成的新型抗生素。作者测定了ＳＬＰ对烧伤创面多元耐药菌株的敏感性。结果显示，革兰氏阴性杆菌对ＳＬＰ与ＣＦＰ的敏感率分别为７７．３％（ｎ＝１６３）和４５．０％（ｎ＝１６９）（Ｐ＜０．０１）。其中硝酸盐阴性杆菌与绿脓杆菌对ＳＬＰ的敏感性分别高达１００％及８８．９％；肠杆菌科细菌对ＳＬＰ的敏感率（７０．１％，ｎ＝１０）亦高于ＣＦＰ（３８．４％，ｎ＝１１２）（Ｐ＜０．０１）。革兰氏阳性球菌对ＳＬＰ与ＣＦＰ的敏感率分别为３７．５％（ｎ＝１２８）和２４．６％（ｎ＝１２６，Ｐ＜０．０５）。其中最为常见的金黄色葡萄球菌对ＳＬＰ与ＣＦＰ的敏感率分别为４２．６％（ｎ＝６１）和２１．３％（ｎ＝６１）。这表明，青霉烷砜可有效抑制常见病原菌产生的β－内酰胺酶，使抗生素呈现良好的抗菌活性而恢复耐药菌株的敏感性。
AbstractSulperazone(SLP),a combination of sulbactam(β-lactamase inhibitor)with cefoperazone(CFP),wasstudied in vitro for its sensitivitv to multi-resistant strains of bacterhia isolated from burn wounds. The re-sults showed that the sensitive rate of gram-negativebacteria to SLP was 77. 3%(n=163),higher than thatof CFP(45.0%,n=169)(P< 0. 01).The rate ofpseudomonas aeruginosa which was common among thegram-negative bacteria was 88.9%(n=45),much high-er than that of CFP(71.7%,n=46)(P<0.05);Therate of bacterium anitratum was 100%, and it was re-sistant to CFP (P<0.01 ).The sensitive rate of gram-positive bacteria to SLP was 37. 5%(n=128) but toCFP was 24.6%(n=126)(P<0.05). The rate ofstaphylococcus aureus which was common in gram-pos-itive bacteria was 42.6%(n=61), much higher thanthat of CFP (21.3%,n=61)(P<0.05).It is indicatedthat sulbactam inhibits most β-lactamases produced bycommon bacterial pathogens and makes antibiotics re-store the sensitivity to resistant strains. Sulperazone ispromising in the treatment of burn infection.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1995年第7期390-392,共3页
Chinese Journal of Surgery
