摘要
观察加用青霉烷砜后氨苄青霉素对痢疾杆菌的体外杀菌效果。结果表明,加用青霉烷砜后对69株痢疾杆菌的杀菌效果,从单纯氨苄青霉素的杀菌率59.4％(41/69)提高到98.6％(68/69),有显著增效作用(P<0.005)。各株痢疾杆菌对国产和墨西哥产氨苄青霉素的敏感性无差异。证明青霉烷砜对氨苄青霉素有增效作用,对原耐氨苄青霉素痢疾杆菌的杀菌率达96.4％(27/28)。对耐药痢疾杆菌治疗药物的选择提供了有益的参考。
An in vitro study of bactericidal effect of sulbactam when cooporated with ampicillin against 69 isolates of Shigella is reported. The bactericidal rate of sulbactam and ampicillin (98. 60%, 68/69) was significantly riased than that of ampicillin alone (59. 41 % , 41. 69) , (P<0. 01). There is no dif-ferance between the ampicillin made in China and that from Mexico. The sensitivty of ampicillin resistant shigella isolates to sulbactam/ampillin was 96. 40%(27/28). It is benefitial to the physician in choosing efficient antibiotic against drug resistant shigella.
出处
《湖南医科大学学报》
CSCD
1990年第4期361-362,共2页
Bulletin of Hunan Medical University
关键词
青霉烷砜
氨苄青霉素
药物协同作用
sulbactam
ampicllin
drug combinations
shigella
drug resistance
