摘要
以不同剂量白念珠菌（白念）经日攻击健康小鼠，其对肠粘膜的粘附量与菌量成正比；地塞米松、氨甲蝶呤、四环素等均可促进粘附并向内脏播散甚或致死，提示肠道携带白念是免疫低下宿主并系统感染的重要储存灶。几丁质可降低粘附，可考虑作为预防措施之一。
Challenged with various doses of Candida albicans by oral intragastric route colonization of Candida albicans on the gastrointestinal (GI) tract was observed. The results showed that the percentage of Candida albicans adherent to the intestinal mucose was proportional to the doses of fungi. Dexamethasone, methotrexate and tetracycline could all increase the adherence of Candida to the GI mucosa, and partly disseminated to other organs leading the mice to death. It suggests that colonization of Candida on GI is an important reservior in immunocompromised hosts. Chitins have the effect to inhibit the adherence and can be considered as a means for prophylaxis.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1994年第2期86-88,共3页
Chinese Journal of Dermatology
基金
国家自然科学基金资助项目
