摘要
本文研究了３Ｈ－ＴＮＴ在大鼠体内的毒物动力学。ＴＮＴ的生物半衰期为９．３ｈ，经气管内注入ＴＮＴ的生物利用度为８８．１７％。ＴＮＴ在工人体内的代谢物２．６－二硝基－４－氨基甲苯（ＤＮＡＴ）主要经尿排出，其排出量与ＴＮＴ接触水平有关，与ＴＮＴ皮肤污染量相关更为密切，提示有接触水平－效应关系，测定尿中ＤＮＡＴ可作为职业接触ＴＮＴ的生物监测指标。根据ＴＮＴ毒物动力学参数和ＴＬＶ值的推算结果，结合职业接触ＴＮＴ的人群资料，参考非接触人群尿中ＤＮＡＴ的本底值，初步提出ＴＮＴ生物接触指数（ＢＥＩ）为１ｍｇ／Ｌ。
oxicokinetics of3H-trinitrotoluene(TNT) was studied in rats。The
results showed that biological half-life(1/2)Was 9.3 h and inhalation bioavailability(F)was
88.17%。 DNAT(2,6-dinitro-4-aminotoluene),an importantmetabolite of TNT,is mainly excreted
through urine。The amount of DNAT elimination in urine was dependent onthe level of TNT
exposure,especially of the skin contamination。Determination of DNAT in urine may be used
asan index of TNT biological monitoring。 Based on the toxicokinetic parameters of TNT and
the estimation of TLV,as well as the data of biological monitoring in exposed population and the
background DNAT in urine of non-eX-posed population,the biological exposure index(BEI)in
urine for occupational exposure of TNT is suggested to be1mg/L DNAT。
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1994年第1期19-21,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
毒物动力学
生物接触指数
梯恩梯
Trinitrotoluene(TNT )Toxicokinetics Biological exposure index(BEI)
