摘要
目的探讨长期接触低浓度ＴＮＴ的神经行为学效应及生物学监测指标。方法应用ＷＨＯ－ＮＣＴＢ测定接触ＴＮＴ工人的早期神经行为改变并收集工人班末尿，测定尿中２，６－二硝基－４－氨基甲苯（ＤＮＡＴ）的含量。结果（１）长期接触低浓度ＴＮＴ可影响神经行为。主要表现为惰性情绪增加，记忆及运动稳定性降低。（２）尿ＤＮＡＴ含量明显增加，与ＮＣＴＢ得分存在一定接触－效应关系。结论神经行为学测试可作为检测ＴＮＴ接触工人早期影响的检测指标。ＮＣＴＢ得分与尿ＤＮＡＴ含量间具有较好相关性。
Objective To explore the effect on workers with low level and long term exposure to TNT and its biological monitoring.Methods Neurobehavilral changes were assessed using NCTB recommended by WHO,meantime the urine samples were collected at the end of work shift for the analysis of 2,6 dinitro 4 aminotoluene(DNAT).Result There was an adverse effect on mood states,coordination memory and visuoconstructive abilities in TNT exposed workers.A relationship was found between urinary DNAT excretion and NCTB score.Conclusions It showed that neurobehavioral test can be used as a tool for the detection of early effects by TNT,the declined scores of most NCTB tests were correlated with the increased DNAT excretion,and the level of urinary DNAT may reflect the exposure level.
出处
《中国工业医学杂志》
CAS
1998年第5期257-260,共4页
Chinese Journal of Industrial Medicine
