摘要
本文简要报告了肼、甲基肼、偏二甲基肼、苯乙烯、芥氧氮丙烷、丙二醇二硝酸酯、1-和2-位的丙二醇一硝酸酯、甲基丙烯酸甲酯、甲基丙烯酸环氧丙酯、硫膦、甲胺磷的毒物力动学研究结果。结合我们的实际经验,本文讨论了毒物动力学研究的主要目的、对象、内容和范围、经皮接触和吸入接触的毒物动力学研究、毒物动力学与毒效动力学的联接和在毒理学研究中毒物动力学与毒效动力学同步模型的应用。
Recently the toxicokinetics of hydrazine, monomethylhydrazine, unsymdimethylhydrazi-ne, styrene, metepa, 1, 2-propylene glycol dinitrate, 1-propylene glycol mononitrate, 2-propylene glycol mononitrate, 2 -propylene glycol mononitrate, methyl methacrylate, gly-cidyl methacrylate, sulfur mustard and methamidophos were studied in our laboratory.According to the practical experience of our laboratory the following aspects of toxicok-inetics will be discused:l.The main purpose, object, content and range of toxicokinetic studies,2.The toxicokinetic studies of percutaneus exposure.3.The toxicokinetic studies of inhaled exposure.4.The linking of toxicokinetics and toxicodynamics.5.The application of the simultaneous modeling of pharmacokinetics and pharmacodyn-amics to the studies of toxicology.
出处
《卫生毒理学杂志》
CSCD
1992年第2期72-74,93,共4页
Journal of Health Toxicology
