摘要
目的:观察抗精神病药对首发精神分裂症患者认知功能和事件相关电位P300的影响。方法:对67例患者(病例组),采用随机对照研究连续观察12周,其中利培酮组32例,奎硫平组35例,另选择正常对照组32名。进行阳性与阴性症状量表(PANSS)、韦氏记忆量表(WMS)和事件相关电位P300的测评。结果:首发精神分裂症患者在长时记忆、短时记忆、瞬时记忆及记忆商数(MQ)受损较为明显,与正常对照组比较差异有显著性(P<0.05)。P300电位成分中P2、N2及P3潜伏期明显延长,P2及P3波幅明显降低,与正常对照组比较差异均有显著性(P均<0.05)。奎硫平组及利培酮组患者治疗后WMS的再认、联想、理解及MQ均明显高于治疗前,两组患者治疗后WMS各项目之间比较差异均无显著性;两组患者在治疗前后P300各指标之间差异无显著性。结论:首发精神分裂症患者存在认知功能障碍,奎硫平与利培酮对首发精神分裂症患者认知功能的作用相当。
Objective:To compare the effects of antipsychotic drugs on cognitive function in first-episode schizophrenic patients.Method:Sixty-seven patients with first-episode schizophrenia were divided randomly into two groups treated with quetiapine(n=35) or risperidone(n=32).positive and negative symptom scale (PANSS),wechsler menory scale (WMS) and P_(300) were used to evaluate the effects of drugs and cognitive function.32 normal controls were also tested these items.Results:Compared with the normal controls,the long-term memory,short-term memory,immediate memory and MQ of first-episode schizophrenia were damaged obviously;the latency periods of P_2,N_3 and P_3 of P_(300) potentials was longer,while the amplitudes of P_2 and P_3 of P_(300) potentials were lower(P<0.05).The recognition,association,comprehension and MQ of WMS increased significantly after treatments in both groups,no differences in WMS and P_(300) were found between them.Conclusion:The patients with first episode schizophrenia have cognitive dysfunction.It is suggested that both quetiapine and risperidonecan improve cognitive function.
出处
《临床精神医学杂志》
2005年第3期168-170,共3页
Journal of Clinical Psychiatry
基金
河南省自然科学基金资助项目(编号994024500)
