摘要
目的了解奎硫平与利培酮治疗精神分裂症的疗效和不良反应的差异.方法应用Meta分析对10项研究奎硫平与利培酮治疗精神分裂症对照研究的文章进行再分析,评价其合并效应量的大小和综合显著性检验.结果①奎硫平治疗前后的自身对照,合并效应量d=2.571,95%CI(1.192,3.950),综合显著性检验χ2＝13.358,P<0.001,提示奎硫平治疗精神分裂症前后症状学变化有非常显著性差异,效应极强.②奎硫平与利培酮的组间比较,d=-0.0919,95%CI(-0.367,0.182),综合显著性检验χ2＝0.4309,P>0.05,提示这两种药物的疗效没有显著性差异,差异效应弱.③奎硫平组的头昏、嗜睡不良副反应比利培酮组多,差异具有显著性(χ2＝20.425,P<0.05;χ2＝8.554,P<0.05),利培酮组的月经紊乱、锥体外系副反应(EPS)、体重增加等不良副反应均比奎硫平组多,具有显著性差异(χ2＝3.903～52.224,P均<0.05),其余副反应均无显著性差异.结论奎硫平与利培酮的疗效无显著性差异,副作用有明显不同.
Objective To study the difference in therapeutic effects and side effects between quetiapine and risperidone. Methods Ten comparative studies of quetiapine and rispendone in the treatment of schizophrenia were analyzed by recta-analysis in therapeutic effects and side effects. Results 1. The significant difference on symptom between before and after treatment with quetiapine was found, d= 2.571,95% CI（1.192,3. 950）, χ^2 = 13. 358, P〈0. 001. 2. No significant difference on clinical efficacy between quetiapine group and risperidone group,d=-0. 0919,95%CI（-0. 367,0. 182）,χ^2=0. 4309,P〉0. 05. 3. The incidences of dizziness and somnolence in quetiapine group were significantly higher than those in risperidone group（χ^2=20. 425 ,P〈0. 001; χ^2= 8. 554,P〈0.01）,but the incidences of menoxenia.EPS and weight gain in quetiapine group were significantly lower than those in risperidone group（χ^2=3. 903～52. 224,P〈0.05）, the other side effects were not signifinicantly different. Conclusion The therapeutic effects of quetiapine and risperidone for treating schizophrenia were similar,and the side effects of the two drugs were different.
出处
《山东精神医学》
2005年第4期240-243,共4页
Shangdong Archives of Psychiatry
