摘要
采用沉淀法和高速组织捣碎机法研究了萘普生－β－环糊精包含物的制备工艺。测定包合物的溶出速率和红外光谱。结果表明：高速组织捣碎机法优于沉淀法，所得包合物中萘普生与β－环糊精的摩尔比为１：１，且试验重现性好，溶出速率显著提高，２０ｍｉｎ时溶出量为萘普生单体的１６．５倍。
The inclusion complex between naproxen (1) and β-cyclodextrin was prepared by precipitation method (Ⅰ)and high speed tissue-smash machine method (Ⅱ). The dissolution rate and IR spectrum of the inclusion complex were determined. The results showed that method Ⅱ was better than method Ⅰ.When the inclusion complex is in a 1:1 molar ratio the dissolution rate was remarkably increased, and the amount of drug released in 20 min is 16.5 times that of the pure 1.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第12期540-543,共4页
Chinese Journal of Pharmaceuticals
关键词
萘普生
环糊精
包合物
溶出速率
解热镇痛药
naproxen,β-cyclodextrin, inclusion complex, dissolution rate,IR absorption spectroscopy
