摘要
采用饱和水溶液法制备了萘普生-β-环糊精包合物(Nap-β-CYD)。经正交试验优选出最佳制备工艺条件为:Nap2mmol,n(Nap)∶n(β-CYD)=1∶1,搅拌(800r·min-1)下于70℃反应1h。Nap-β-CYD经UV,IR,扫描电镜和X-ray衍射表征。Nap-β-CYD在水中的溶解度为Nap的4.8倍。
The inclusion complex of naproxen-β-cyclodextrin（Nap-β-CYD） was prepared by saturated aqueous solution method. The preparation process of Nap-β-CYD was optimized with orthogonal experiments, which were as follows： Nap was 2 retool, n（Nap） ： n（β-CYD） was 1 ： 1, the reaction was carried out at 70 ℃ for 1 h under stir rate of 800 r·min^-1. The structure of Nap-β-CYD was characterized by UV, IR, scanning electron microscopy and X-ray diffraction. The solubility of Nap-β-CYD in water was 4.8 times higher than that of pure Nap.
出处
《合成化学》
CAS
CSCD
2007年第1期65-68,共4页
Chinese Journal of Synthetic Chemistry
关键词
萘普生
Β-环糊精
包合物
正交试验
表征
naproxen
β-cyclodextrin
inclusion complex
orthogonal experiment
characterization
