摘要
本文采用普萘洛尔（１５ｍｇ·ｋｇ－１·ｄ－１×７ｄｉｐ），双侧颈上神经节切除以及松果腺切除法观察了白芍总甙（ＴＧＰ）和丹皮总甙（ＴＧＭ）对松果腺调节炎症，免疫反应的影响。
Effects of total glucosides of paeonytTGP) and total glucosides of moutan cortex (TGM)on the function of pineal gland in inflammatoryimmunoregulation in rats were studied by means ofindirect pinealectomy [propranolol (Pro),superiorcervical ganghonectomy [SCGX)] and directpinealectomy (PX).In normal rats,concanavalin A(Con Aj and hpopolysaccharide (LPS)-inducedproliferation of lymphocytes and Con Ainducedinterleukin 2 (IL2) production of splenocytes were inhibited by Pro and SCGX respectively. Con A andLPSinduced proliferation of splenocytes wassignificantly suppressed by PX in both normal andadluvant arthntis (AA) rats.PX of normal rats coulddecrease IL-1 production which was increased furtherin PX AA rats.Melatonin (10μg·kg-1·d-1 ip), TGP(50 mg·kg-1·d -1 ig).and TGM(10 mg·kg-1·d -1.ig)administrated once a day at 1600 could antagonizethe immune changes caused by PX.These suggestthat melatonin is an important inflammatoryiminunoregulatory agent. the effects of TGP and TGMon inflammatoryimmunoregualtory activity could bemediated by pineal gland.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第3期161-165,共5页
Chinese Journal of Pharmacology and Toxicology
关键词
皂甙
白芍
丹皮
松果腺
关节炎
glucosides, paeony,moutan cortex.pineal body,arthritis.adjuvant,inflammation,lmmunlzation
