摘要
目的：观察松果腺功能低下大鼠的细胞免疫的变化及白芍总甙（ＴＧＰ）的作用。方法：主要应用傍晚腹腔注射普萘洛尔或大鼠双侧颈上神经节切除造成松果腺功能低下的模型。结果：下午４：００腹腔注射普萘洛尔（１５ｍｇ·ｋｇ－１·ｄ－１×７ｄ）可引起Ｔ、Ｂ淋巴细胞转化率降低、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）能使普萘洛尔降低的Ｔ、Ｂ淋巴细胞免疫功能恢复正常；双侧颈上神经节切除造成大鼠胸腺及脾淋巴细胞的致分裂素反应降低，ＩＬ－２生成减少、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）可反转双侧颈上神经节切除的作用。结论：ＴＧＰ的免疫调节作用与松果腺有关。
AIM:The effects of evening administration propranolol and SCGX on immunity system were observed, meanwhile influence of TGP on the pineal gland was studied. METHODS: A the pineal gland malfunctional model was found by peritoncal injection of propranolo(4:00 pm, 15 mg·kg -1 ·d -1 ,7 d) and SCGX. TGP (20 mg·kg -1 ·d -1 ,ip or or 50 mg·kg -1 ·d -1 ,7 d po) was used respective. RESULTS: Propranolo could decrease proliferative responses of lymphocytes to ConA and LPS. TGP could antagonize the effects of propranolol on immunity system. Following SCGX the proliferation of T and B cell was inhibited and IL 2 prodution was decreased. TGP could resume some immune function. CONCLUTION: It suggested that the TGP could modulate the immune function through the pineal gland.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1997年第4期372-374,共3页
Chinese Pharmacological Bulletin
关键词
松果腺
白芍总甙
细胞免疫
pineal gland
superior cervical ganglionectomy
propranolo
total glucosides of paeony
cell immunity
interleukin 2
