摘要
本文研究了丹皮总甙(TGM)和日芍总甙(TGP)对渗透性溶血及对H_2O_2引起的红细胞氧化溶血的抑制作用。结果表明:TGP和低浓度的TGM具有抑制红细胞渗透性溶血的作用,而较高浓度的TGM(100mg·L^(-1))则有促进溶血的作用。TGM和TGP均能显著抑制H_2O_2引起的溶血反应,TGM的作用强于TGP。TGM和TGP及Vit E均可抑制H_2O_2 引起的红细胞还原型谷胱甘肽的消耗和脂质过氧化物的产生。
The inhibitory effects of total glucosides of Moutan Cortex (TGM) and to talglucosides of Paeony Lactiflora (TGP) on osmotic hemolysis and oxidative hemolysis induced by hydrogen peroxide were studied. TGM at lower concentration and TGP could inhibit osmotic hemolysis significcantly, but higher concentration (100mg · L-1) of TGM had a hemolytic activity. TGM and TGP could inhibit hemolysis induced by H2O2 significantly,
but TGM was more effective than TGP. TGM .TGP and Vit E all could inhibit lipid peroxidation and glutathione depletion, induced by H2O2, on erythrocytes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第3期202-205,共4页
Chinese Pharmacological Bulletin
关键词
丹皮总甙
白芍总甙
渗透性溶血
total glucosides of Moutan Cortex (TGM)
total gluosides of Pae-ony Lactiflora (TGP) osmotic hemolysis oxidative hemolysis hydrogen peroxide
