摘要
目的:研究贯郁胶囊对嗅球损毁大鼠行为及大脑皮层单胺类神经递质的影响。方法:采用敞箱法、跳台法观察嗅球损毁模型大鼠的行为变化;采用高效液相电化学方法分析贯郁胶囊对嗅球损毁模型大鼠神经递质含量的影响。结果:嗅球损毁模型大鼠敞箱实验的爬格数和站立数显著增加,跳台实验的错误次数明显增多(P<0.01);大脑皮层5羟色胺(5HT)的含量明显降低,3,4二羟基苯乙酸(DOPAC)/多巴胺(DA)均明显升高(P<0.01)。贯郁胶囊1.2,0.6g·kg-1均可降低嗅球损毁大鼠敞箱实验的爬格数和站立数,减少跳台实验的错误次数(P<0.01,P<0.05),提高大脑皮层中5HT的含量,并使DOPAC/DA恢复正常(P<0.01)。结论:贯郁胶囊能改善嗅球损毁模型大鼠的行为异常,作用机制与调节5HT的含量、DA的代谢有关。
Objective: To investigate the behavioral changes and the levels of monoamine neurotransmitters in the anterior cortex in the olfactory bulb damage rats after being treated with Guanyu capsules (GYC). Method: Open-field test and step-down passive avoidance test were used to observe the behavior in model rats. HPLC-ECD was used to analyze the influences of GYC on the levels of monoamine neurotransmitters. Result: In the model rats, there was a characteristic hyperactivity in the Open-field and learning deficits in step-down passive avoidance(P<0.01). The contents of 5-HT reduced, and the rate of DOPAC/DA increased significantly (P<0.01). GYC 1.2, 0.6 g·kg^(-1) could correct behavioral changes increase the contents of 5-HT, and decrease DOPAC/DA level (P<0.01). Conclusion: GYC can correct behavioral changes in rats model of olfactory bulb damage, and regulating 5-HT and DA metabolism in cortex is one of the antidepressive mechanisms of GYC.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第10期782-785,共4页
China Journal of Chinese Materia Medica
