摘要
目的:探讨苏郁胶囊对双侧嗅球损伤抑郁模型大鼠行为学及下丘脑-垂体-肾上腺(HPA)轴的影响。方法:48只雄性大鼠随机分为假手术组、模型组、苏郁胶囊高、中、低剂量组(22.8、11.4、5.7g/kg)及氯米帕明组(0.02g/kg)。应用双侧嗅球损伤复制大鼠抑郁模型,敞箱法及跳台法测定大鼠的行为学指标;放射免疫方法测定大鼠血浆促肾上腺皮质素释放激素(CRH)、促肾上腺皮质激素(ACTH)及皮质醇(CORT)的水平。结果:苏郁胶囊可不同程度降低双侧嗅球损伤大鼠敞箱实验的水平运动次数与垂直运动次数;增加双侧嗅球损伤大鼠跳台实验的潜伏期及减少错误次数;同时降低双侧嗅球损伤大鼠血浆CRH、ACTH和CORT含量。结论:苏郁胶囊能逆转双侧嗅球损伤抑郁模型大鼠的行为异常,其可能与苏郁胶囊有效地拮抗HPA轴功能亢进相关。
AIM： To study the effects of Suyu capsule on behaviors and hypothalamus-pituitary-adrenal axis in depression model rats induced by bilateral olfactory bulb impairment. METHODS： 48 male SD rats were randomly divided into 6 groups including the sham group, the model group, and three Suyu capsule groups（The doses were 22.8, 11.4, 5.7 g/kg, respectively） and Clomipramine group （0.02 g/kg）. The depression model was established by bilateral olfactory bulb impairment. The behaviors of rats were observed using open-field and step-down test. The levels of CRH, ACTH and CORT in plasma of rats were detected by radioimmunoassay （ RIA ）. RESULTS ： Suyu capsule could decrease the numbers of crossing and rearing of depression model rats using the Open-Field test. Suyu capsule increased the latent time and diminish the mistakes for the depression model rats in the step-down test, Suyu capsule also decreased the levels of CRH, ACTH and CORT in plasma of depression model rats. CONCLUSION： Suyu capsule could reverse the behavioral changes of depression model rats induced by bilateral olfactory bulb impairment, which may be related to Suyu capsule effectively antagonize hypothalamus-pituitary-adrenal axis hyperfunction.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第2期163-166,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
卫生部科学研究基金-浙江省医药卫生重大科技计划(WKJ2007-2-020)
浙江省卫生高层次创新人才培养工程项目
浙江省自然科学基金项目(X206952)
浙江省中医药科技计划重点项目(2006Z001)
关键词
苏郁胶囊
抑郁症
双侧嗅球损伤
行为学
下丘脑-垂体-肾上腺轴
Suyu capsule
depressive disorder
bilateral olfactory bulb impairment
behavior
hypothalamus-pituitary-adrenal axis
