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基质金属蛋白酶基因多态性的研究进展 被引量：16

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摘要 基质金属蛋白酶(metal matrix proteinase,MMPs)是一个蛋白水解酶家族,可降解细胞外很 多基质成分。近年来随着分子生物学的进展,对MMPs的结构、功能及生理病理作用已进行了较为深入 的研究,尤其对MMPs在肿瘤侵袭、转移中的作用越来越重视。目前已发现MMPs基因有一些多态性位 点可影响MMPs的结构与功能,且与疾病的发生、发展有关。本文对近些年关于MMPs的多态性研究进 展做一综述。
作者 金霞 张健慧
机构地区 河北省肿瘤研究所
出处 《国外医学（遗传学分册）》 2005年第2期76-79,共4页 Foreign Medical Sciences(Section of Genetics )
基金 国家基金委(No.30371591)
关键词 酶基因多态性 基质金属蛋白酶 MMPS matrix 蛋白水解酶 分子生物学 多态性位点 多态性研究 基质成分 病理作用 肿瘤侵袭 Ps基因 细胞外 可降解 结构
分类号 R346 [医药卫生—基础医学]
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参考文献36

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二级参考文献52

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国外医学（遗传学分册）
2005年 第2期

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