摘要
目的探讨基质细胞衍生因子(SDF-1)、基质金属蛋白酶-7(MMP-7)在乳腺癌中的表达及相互关系。方法采用免疫组化SP法检测50例乳腺癌和33例正常乳腺组织中SDF-1和MMP-7的蛋白表达,并进行相关分析。结果SDF-1、MMP-7在乳腺癌组织中的表达为76%和72%,与正常乳腺组织的表达(33%和27%)比较,差异有显著性(P<0.01)。其中SDF-1表达在患者肿瘤大小、淋巴转移两项指标上存在组间差异(P<0.05,P<0.01),MMP-7表达在淋巴转移方面存在组间差异(P<0.01)。SDF-1和MMP-7两种蛋白表达之间存在相关性(P<0.05)。结论SDF-1和MMP-7在乳腺癌的发生发展中可能有重要协同作用。
Objective To inverstigate the expression and relationship of Stromal cell - derived factor - 1 （ SDF - 1 ） and Matrix metalloproteinases - 7 （ MMP - 7 ） proteins in breast carcinoma. Methods Immunohistochemical assay was used to detect the expression of SDF - 1 and MMP - 7 proteins in 50 breast cancerous tissues and 33 control breast tissues. Results The positive rates of SDF - 1 and MMP - 7 in breast cancerous tissues were 76% and 72%. When compared with control group （ 33.3 % and 27.3 % ）, the differences were significiantly （ P 〈 0.01 ）. The expressions of SDF - 1 were different signifieiantly between the groups of tumor - volume and lymph - node - metastasis （ P 〈 0.05, P 〈 0.01 ） ; The expressions of MMP- 7 were different significiantly too between the groups of lymph- node- metastasis（ P 〈 0.01 ）. The expression of SDF - 1 protein had positive relationship with that of MMP - 7 proteinin Breast Carcinoma（ P 〈 0.05 ）. Conclusions SDF - 1 and MMP - 7 proteins might play a synergetie role in process of breast carcinoma.
出处
《南华大学学报（医学版）》
2009年第1期42-44,共3页
Journal of Nanhua University(Medical Edition)
关键词
SDF-1
MMP-7
乳腺癌
stromal lell - derived faetor
Matrix metalloproteinases -7
breast carcinoma
