摘要
表研究以MNNG诱发了13例大白鼠胃平滑肌肉瘤。肿瘤原发于肌层,向胃外(7例)、胃壁内(3例)与胃腔内(3例)生长。均经HE、嗜银、VG、Masson’s三色与PTAH染色及电镜证实,低度恶性8例,高度恶性5例。其发生机理可能与MNNG浓度高、胃粘膜通透性增高、粘液细胞增生取代壁细胞致胃酸分泌减少,MNNG活性增强以及吐温加速MNNG溶解更易渗入肌层有关。
Thirteen cases of gastric leiomyosarcoma were unexpectedly induced after administration of MNNG (500μg/ml) in Wistar rats. The frequencies of low grade and high grade leiomyosarcomas were 29.6%(8/27) and 33.3%(5/15) respectively. The tumorigenesis may be related to high concentration of MNNG, increase in mucosal permeability, enhancement of activity of MNNG because of decreased secretion of gastric acid due to lack of parietal cells and more rapid dissolution of MNNG with Tween, a fact that facilitated permeation into deeper smooth muscle layer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1993年第2期137-139,F002,共4页
Chinese Journal of Clinical Oncology
关键词
肉瘤
光镜
透射电镜
胃肿瘤
Wistar rat
Gastric leiomyosarcoma
Electronmicroscopic observation
N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)
