摘要
目的探讨氯沙坦对脂肪肝模型鼠病理形态学改变的影响。方法Wistar 大鼠30只,随机分成正常对照组、模型组和治疗组,采用CCL4皮下注射构建脂肪肝模型。行HE、苏丹Ⅲ和VG染色,判断肝脂肪变性、炎症和纤维化的程度。结果正常对照组、治疗组的肝脂肪变性、炎症和纤维化程度明显低于实验模型组,分别为P<0.005和P<0.05。结论氯沙坦对大鼠脂肪肝具有防治作用。
To study the effect of losartan on pathomorphology of fatty liver rats. Thirty healthy Wistar rats were randomly divided into three groups: normal control group, experiment model group and losartan-treated group. Fatty liver models were established in the latter 2 groups by injecting CCL4. Liver sections were stained by hematoxylin-eosin,Sudan Ⅲ and van Gieson to evaluate the degree of inflammation, fatty liver and hepatic fibrosis. The degree of inflammation, fatty liver and fibrosis in the liver tissue of normal control group and losartan-treated group was lower obviousty than that of experiment model group, P <0.005 and P <0.05 respectively). [Conclusion] Losartan may play a important role in the prevention and treatment of fatty liver in rats.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第1期44-46,共3页
China Journal of Modern Medicine
基金
湖南省卫生厅课题资助(NO:Y02-010)
