摘要
目的 :检测非酒精性脂肪肝肝纤维化指标 ,探讨其临床意义。方法 :符合 B超诊断的非酒精性脂肪肝患者作肝纤维化指标检测 ,并以肝炎后肝硬化患者和不嗜酒的健康者作为对照。结果 :脂肪肝患者 型前胶原 (PC )、透明质酸 (HA)、 型胶原 (C )、层粘蛋白 (LN)均高于健康者 (P<0 .0 5～ 0 .0 1) ,低于肝硬化患者 (P<0 .0 1) ;重度脂肪肝与轻度脂肪肝之间 PC 、C 、LN差异均有显著性 (P<0 .0 5～ 0 .0 1) ,且阳性率较高。结论 :重度脂肪肝患者存在不同程度的肝纤维化趋向 ,肝纤维化指标的多项联检对脂肪肝肝纤维化的判断与防治有积极意义。
Objective: To assess the clinical utility of liver fibrosis indexes determination in patients with nonalcoholic fatty liver disease.Methods:Liver fibrosis indexes of 79 patients with fatty liver,diagnosed by B ultrasonic echography,37 patients with posthepatitic cirrhosis patients and 32 healthy subjects were determined.Results:The level of procollagen Ⅲ(PCⅢ),hyaluronic acid (HA),collagenⅣ(CⅣ),laminin (LN) in the fatty liver cases were significantly higher than those of healthy subjects (P<0.05~0.01), but lower than those in the liver cirrhosis cases (P<0.01).The difference of PCⅢ,CⅣ,LN between the severe and early fatty liver cases was significant(P< 0.05~ 0.01).Positive rate of these indexes was higher in severe cases.Conclusion:There is a trend of liver fibrosis in severe fatty liver patients.Combined determination of liver fibrosis indexes may help the diagnosis of liver fibrosis in the fatty liver patients.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2003年第3期241-243,共3页
Journal of Zhejiang University(Medical Sciences)
