摘要
目的 :探讨葡萄糖转运蛋白 1(GLUT1)和碱性成纤维细胞生长因子 (bFGF)在甲状腺恶性肿瘤中的表达、作用以及两者在甲状腺恶性肿瘤发生发展过程中的关系。方法 :应用免疫组织化学方法检测GLUT1、bFGF两者在甲状腺癌、甲状腺腺瘤和甲状腺正常组织中的表达。结果 :GLUT1、bFGF的表达与甲状腺组织性质有关 ,恶性肿瘤高于腺瘤和正常组织。同时和病理分类、临床分期及淋巴结转移有密切的关系。GLUT1、bFGF之间呈正相关性。结论 :GLUT1、bFGF异常表达在甲状腺癌的发生发展中起重要作用 ,可促进甲状腺肿瘤细胞的恶性增殖和侵袭转移。GLUT1、bFGF表达强度作为判断甲状腺癌的恶性程度的检测指标 ,具有临床应用的价值 ,可为治疗提供参考价值。
Objective: To study the express and function relations of glucose transporter-l(GLUT 1) and basic fibroblast growth factor (bFGF) in the development of thyroid carcinomas.Methods: Immunohistochemistry method (SP) was used to examine the expression of GLUT 1 and bFGF on the thyroid carcinomas, thyroid adenomas and normal thyroid tissue.Results: The expression of GLUT 1 and bFGF was related to the character of thyroid tissue.The expression of GLUT 1 and bFGF in thyroid tumor was higher than in the thyroid adenomas and normal tissue. At the same time, it had a close relation with thyroid carcinomatous pathological type,TNM stage and lymphnode metastasis .The relation between GLUT 1 and bFGF was postive.Conclusion: The abnormal expression of GLUT 1 and bFGF plays an important role in the origin and development of thyroid cancer and it can promote the thyroid tumor cells' malignant mulplication and transportation.The expression of GLUT 1 and bFGF can be used as the checkpoint and has practical meaning in clinic and it can provide reference for treatment.
出处
《河南医学研究》
CAS
2004年第4期299-301,共3页
Henan Medical Research
