摘要
目的 探讨CK19、CK2 0、bFGF的表达及其与膀胱移行细胞癌 (TCC)生物学行为之间的关系。方法 采用免疫组化方法对 5 4例TCC标本中CK 19、CK2 0、bFGF的表达进行检测 ,并进行分组比较。结果 CK19的表达在有否复发组之间有显著性差异 (P <0 .0 1) ,在不同的病理分级和临床分期之间差异无显著性 (P >0 .0 5 )。CK2 0的表达在不同的病理分级、临床分期及有否复发组间差异有显著性 (P <0 .0 5 ,P <0 .0 1,P <0 .0 0 0 1)。bFGF的表达在不同的病理分级、临床分期和有否复发组之间差异均有显著性 (P <0 .0 5 )。结论 CK19、CK2 0、bFGF的表达与TCC生物学行为密切相关 ,为临床更好地诊断膀胱肿瘤、观察疗效。
Objective To investigate the expressions of cytokeration 19 (CK19)?cytokeration 20 (CK20) and basic fibroblast growth factor (bFGF) in judging the bladder transitional cell carcinoma (TCC) and to evaluate their significance in biological behavior of tumor. Methods The expressions of CK19? CK20 and bFGF were examined in 54 cases with TCC by immunohistochemical method.Results CK19 expression was significantly different between recurrent group and non-recurrent group (P<0.01), and was not significantly different among tumor grades?clinical stages; CK20 expression was significantly related to tumor grade?clinical stage and recurrence (P<0.05,P<0.01,P<0.0001, respectively); bFGF expression was significantly related to tumor grade?clinical stage and recurrence (P<0.05).Conclusions The expressions of CK19?CK20 and bFGF were significantly related to biological behavior of TCC, that provide some theoretical basis for clinician to diagnosis bladder carcinoma?to observe curative effect and to predict recurrence better.
出处
《临床外科杂志》
2002年第1期32-34,共3页
Journal of Clinical Surgery
