摘要
目的综合分析Fas配体(FasL)与胃癌的关系.方法计算机检索5个数据库(CNKI数据库、万方数据库、维普数据库、Springerlink全文期刊数据库、ProQuest全文期刊数据库)1990至2006年间国内外公开发表的关于用免疫组化的方法检测胃癌组织中FasL表达的文献;各文献研究假设与研究方法相似;病例组和对照组诊断明确;对样本大小明确;原始数据提供阳性表达的例数或阳性率.对每个研究进行复习并进行质量评估,对重复报告、研究质量差、信息少或数据不完整而无法利用的文献剔除.使用Review Manager 4.2.10软件进行Meta分析对数据进行处理,估计其合并OR值和95%CI.结果共检索出相关文献49篇.根据文献的入选和排除标准,最终纳入本次Meta分析的共有13篇文献.在胃癌组和正常胃黏膜组的分析研究中,纳入分析10篇文献,结果表明FasL.的表达在胃癌组和正常胃黏膜组之间的差异有统计学意义(OR_(合并)=14.88,95%CI 5.34~41.48;P<0.00001);在不同分化程度的分析研究中,纳入分析8篇文献,结果表明FasL的表达在高中分化型胃癌和低分化胃癌之间的差异无统计学意义(OR_(合并)=1.90,95%CIO0.68~5.28;P=0.22);在不同TNM分期的分析研究中,纳入分析5篇文献,结果表明FasL的表达在Ⅰ、Ⅱ期胃癌组和Ⅲ、Ⅳ期胃癌组之间的差异有统计学意义(OR_(合并)=2.58,95%CI1.05~6.32,P=0.04);在有无淋巴结转移的分析研究中,纳入分析8篇文献,结果表明FasL的表达在有淋巴结转移胃癌患者和无淋巴结转移胃癌患者之间的差异无统计学意义(OR_(合并)=1.00,95%CI0.45~2.21,P=1.00).结论FasL的高表达是胃癌的危险因素,并且和不同的TNM分期有关.
Objective To analyze the relationship between Fas ligand(FasL)and gastric cancer extensively.Methods The computerized CNKI database,Wangfang database,Weipu database,Springerlink fll-ext periodical database and ProQuest full-text periodical database were searched.And,the literatures detecting FasL in gastric cancer with immunohistochemical method which have been published during 1990 to 2006 were also reviewed.The research hypothesis and research method of each literature were the same;the diagnosis of case and control were definite;the size of sample was also definite;the primitive data must offer the number of object whose FasL were expressed positively or offered the positive rate.Each study and its quality were also evaluated.A software Review Manager 4.2.10,was used to analyze the data.and to estimate the overall OR and its 95%CI.Results A tatal of 49 literatures have been reviewed.According to the selection and washing out criteria,13 literatures were used in this Meta-analysis.In the research of gastric cancer group and normal gastric mucosa group,10 literatures wTe used.Between the two groups the expression of FasL has statistical signifcance(OR_(overal)=14.88,95%CI 5.34-41.48;P<0.00001);In the research of different differentiation level,8 literatures were used.Between the two groups the expression of FasL had no statistical signifcance(OR_(overal)=1.90,95%CI0.68-5.28;P=0.22);In the research of different TNM staging,5 literatures were used.Between the two groups the expression of FasL had statistical significance(OR_(overal)=2.58,95%CI 1.05-6.32;P=0.04);In the research of different Lymph node metastasis,8 literatures were used.Between the two groups the expression of FasL has no statistical significance(OR_(overal)=1.00,95%CI 0.45-2.21;P=1.00).Conclusion The high expression of FasL is the high risk of gastric cancer,and TNM staging has some associations with gastric cancer.
作者
吴伟
关鹏
袁媛
周宝森
WU Wei;GUAN Peng;YUAN Yuan;ZHOU Bao-sen(Department of Epidemiology,China Medical University,Shenyang 110001,China;不详)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2007年第S01期25-29,共5页
Chinese Journal of Preventive Medicine
基金
国家“十五”科技攻关项目[2001BA703806(B)]
