摘要
目的探讨白介素8-251位点(IL8-251)的基因多态性与胃癌易感性的关系.方法以胃癌组和健康对照组基因型分布的OR值为效应指标,全面检索相关文献,纳入符合人选标准的文献,应用REVMAN 4.2软件对各研究结果进行异质性检验和效应值合并.共纳入文献8篇,纳入数据合并的8项研究累计病例2114例,对照2505例.结果通过对各研究的(AA+AT)/TT结果的异质性检验得X^(2)值为21.48(P=0.003),随机效应模型计算合并的OR值为1.12(95%CI 0.90~1.40),剔除权重较大的研究后进行的敏感性分析显示其余的各研究同质,固定效应模型的合并OR值为1.21(95%CI 1.06~1.39).结论携带IL8-251 A等位基因的个体发生胃癌的风险增加.
Objective To evaluate the relationship between IL8-251 gene polymorphisms and astric cancer.Methods iteratures were reviewed and selected based on the criteria for inclusion.The Meta-analysis software,REVMAN 4.2,was applied to check the heterogeneity across the studies and caleulating the pooled OR.Results total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included.The X^(2) value was 21.48(P=0.003),and the pooled OR of(AA+AT)vs.TT was 1.12(95%CI0.90-1.40).Large heterogeneity was found among the studies.After the sensitivity analysis,the pooled OR of(AA+AT)vs.TT1.21(95%CI 1.06-1.39).Conclusion IL8-251-A allele might be associated with higher risk of developing gastric cancer.
作者
路滟
王子盾
沈靖
徐耀初
LU Yan;WANG Zi-dun;SHEN Jing;XU Yao-chu(Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing 210029,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2007年第S01期39-42,共4页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金资助项目(30571605)
