AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical characteristics.METHODS:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29&#...AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical characteristics.METHODS:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the brain.Receiver operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical manifestations.RESULTS:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal gyrus.Furthermore,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the curve.The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.展开更多
Context and Justification: Reconstructive spine surgery and the design of implants depend on disc and vertebral measurements, which vary according to racial groups and geographic areas. This variability underscores th...Context and Justification: Reconstructive spine surgery and the design of implants depend on disc and vertebral measurements, which vary according to racial groups and geographic areas. This variability underscores the importance of studying the morphometric characteristics specific to each population. Research Objective: The primary aim of this research was to determine the measurements of spinal components in the Congolese population in order to establish references suitable for local clinical practice. Materials and Methods: Congolese individuals, free from any spinal disorders, participated in a study on vertebral and disc morphology of the lumbar spine after providing informed consent. They underwent computed tomography examinations at medical imaging centers in Brazzaville. The parameters studied included: in axial sections, the transverse diameter (TDb) and sagittal diameter (SDb) of the vertebral bodies, the pedicular transverse diameter (TDp), and in sagittal reconstructions: the height of the vertebral bodies (Hb) and intervertebral discs (Hd). Results: The sample size consisted of 100 subjects (70 men and 30 women), with an average age of 24.47 ± 3.72 years (18 - 30 years). Cranio-caudally, the TDb, DSb, TDp, and Hd showed increasing values, while Hb values were decreasing. In L1, values for both sexes were: TDb = 39.3 ± 3 mm;DSb = 27.3 ± 2.9 mm;Hb = 26.6 ± 2.1 mm;TDp = 8.2 ± 1.8 mm;in L5: TDb = 50.3 ± 4 mm;DSb = 33.6 ± 2.7 mm;Hb = 25.7 ± 2.2 mm;TDp = 14.8 ± 2.1 mm. The Hd values were 8.1 ± 2.1 mm for L1 - L2 and 11.1 ± 2 mm for L5 - S1. Conclusion: Reconstructive spine surgery and the design of implants depend on disc and vertebral measurements, which vary according to racial groups and geographic areas. This variability underscores the importance of studying the morphometric characteristics specific to each population.展开更多
Objective To investigate cerebral structural signatures of the bulbar-and spinal-onset amyotrophic lateral sclerosis(ALS) using voxel-based morphometry on magnetic resonance imaging.Methods The MR structural images of...Objective To investigate cerebral structural signatures of the bulbar-and spinal-onset amyotrophic lateral sclerosis(ALS) using voxel-based morphometry on magnetic resonance imaging.Methods The MR structural images of the brain were obtained from 65 ALS patients(15 bulbar-onset, 50 spinalonset) and 65 normal controls(NC) on a 3.0 T MRI system. Gray matter(GM) volume changes were investigated by voxel-based morphometry, and the distribution of the brain regions with volume changes was compared between ALS and normal controls, as well as between bulbar-onset and spinal-onset ALS based on Neuromorphometrics atlas.Results On voxel-level the decreased volume of brain regions in ALS patients was located in the right precentral gyrus(r Prc Gy) and right middle frontal gyrus compared with that in NC. The bulbar-onset ALS presented extramotor cortex atrophy(fronto-temporal pattern), including left medial orbital gyrus, left inferior temporal gyrus and right middle temporal gyrus; the spinal-onset ALS suffered from motor cortex atrophy(r Prc Gy dominance) and extra-motor cortex atrophy(fronto-temporal and extra-fronto-temporal pattern) compared with NC. The spinal-onset ALS featured by GM volume loss of left postcentral gyrus and bulbar-onset ALS featured by GM volume loss of left middle temporal gyrus compared with each other. Conclusions The asymmetric GM atrophy of the motor cortex and extra-motor cortex represents the common MRI structural signatures of spinal-onset ALS, and sole extra-motor cortex atrophy represents the structural signatures of bulbar-onset ALS. The present study also demonstrated that the pattern of GM damage is likely to distribute wider in spinal-onset ALS than in bulbar-onset ALS.展开更多
BACKGROUND Mild cognitive impairment(MCI)is a transitional state between normal aging and Alzheimer's disease(AD),characterized by subtle cognitive decline.Amnestic MCI(aMCI),in particular,is a critical precursor ...BACKGROUND Mild cognitive impairment(MCI)is a transitional state between normal aging and Alzheimer's disease(AD),characterized by subtle cognitive decline.Amnestic MCI(aMCI),in particular,is a critical precursor often progressing to AD.There is growing interest in understanding the neuroanatomical correlates of aMCI,especially the role of gray matter volume(GMV)in cognitive and motor function decline.This study hypothesized that aMCI patients will exhibit reduced GMV,particularly in brain regions associated with cognition and motor control,impacting both cognitive performance and motor abilities.AIM To investigate the association of GMV with cognitive and motor functions in aMCI.METHODS In this cross-sectional study conducted from March 2022 to March 2024,45 aMCI patients and 45 normal controls from our Department of Geratology were enrolled.Voxel-based morphometry was used to compare GMV between groups.Correlation of differential GMV with cognitive scores and gait parameters was assessed via partial correlation analysis.Linear regression was used to assess associations between whole-brain GMV and gait measures.RESULTS GMV of aMCI region of interest(ROI)1 and ROI2 was negatively correlated with Activities of Daily Living(ADL)score.GMV of ROI6 was positively correlated with the total scores of Mini-Mental State Examination and Cambridge Cognitive Examination-Chinese Version(CAMCOG-C)and negatively correlated with ADL score.In the partial correlation analysis of cognitive and motor function parameters,age,gender,educational level,height,and weight were controlled,and the results showed that CAMCOG-C was negatively correlated with Dual Task of Time Up and Go Test(TUG)duration in the aMCI group.The volume of the left occipital gray matter in the aMCI group was negatively correlated with TUG.GMV of the bilateral frontal gyrus,right orbitofrontal gyrus,right occipital cleft,right supraoccipital gyrus,and left anterior central gyrus was positively correlated with walking speed.CONCLUSION GMV reduction in aMCI correlates with impaired cognition and motor function,emphasizing key roles for prefrontal,occipital,and central regions in gait disorders.展开更多
Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of sev...Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of severe liver disease or cirrhosis.Previous studies have reported spatially distributed structural and functional abnormalities related to HE,but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear.In this study,we performed surface-based cortical thickness comparisons and functional connectivity(FC)analyses between three cross-sectional groups:healthy controls(HC,N¼51),patients with minimal hepatic en-cephalopathy(MHE,N¼50),patients with overt hepatic encephalopathy(OHE,N¼51).In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE,we found significant cortical thickening in the left para-hippocampal gyrus cortex in the OHE group(p<0.001,p¼0.009)as compared to the HC and MHE group respectively,which is further corroborated by the significant correlation between the cortical thickness and digit symbol test(DST)scores.Furthermore,the decreased FC between the right postcentral gyrus and several sensory regions(bilateral somatosensory and visual cortices)was found to be significant in MHE patients as compared to the HC group.Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems(e.g.,visual,motor and sensory),providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE.展开更多
Background:Subcortical ischemic vascular dementia(SIVD)is a common subtype of vascular dementia.Currently,the bilateral common carotid artery stenosis(BCAS)mouse model is the most suitable SIVD rodent model.In this st...Background:Subcortical ischemic vascular dementia(SIVD)is a common subtype of vascular dementia.Currently,the bilateral common carotid artery stenosis(BCAS)mouse model is the most suitable SIVD rodent model.In this study,we investigated the functional and structural impairments in the hippocampus 1 month after BCAS.Methods:We used behavioral tests,laser speckle flowmetry,long-term potentiation,histochemical staining,molecular experiments,and voxel-based morphometry to evaluate the hippocampal impairments.Results:Behavioral studies revealed that BCAS mice exhibited worse performance.Laser speckle flowmetry detected an obvious decrease in cerebral blood flow.The synaptic plasticity of the perforant path-dentate gyrus pathway was inhibited.Decreased fractional anisotropy and increased mean diffusivity were detected in the hippocampus via diffusion tensor imaging data.A reduction in gray matter volume,which was most prominent in the hippocampus and its surrounding areas,was de-tected via voxel-based morphometry analysis.Impairments in cell morphology and myelin integrity were validated using histochemical staining and molecular biology techniques.In addition,the numbers of GFAP+astrocytes and Iba1+microglia in-creased in the hippocampus.Conclusions:Overall,our study demonstrates early functional and structural impair-ments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS,indicating that the hippocampus is vulnerable to chronic cerebral ischemia.展开更多
基金Supported by National Natural Science Foundation of China(No.82160195,No.82460203)Science and Technology Project of Jiangxi Provincial Department of Education(No.GJJ200169)+1 种基金Science and Technology Project of Jiangxi Province Health Commission of Traditional Chinese Medicine(No.2020A0087)Science and Technology Project of Jiangxi Health Commission(No.202130210).
文摘AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical characteristics.METHODS:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the brain.Receiver operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical manifestations.RESULTS:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal gyrus.Furthermore,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the curve.The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.
文摘Context and Justification: Reconstructive spine surgery and the design of implants depend on disc and vertebral measurements, which vary according to racial groups and geographic areas. This variability underscores the importance of studying the morphometric characteristics specific to each population. Research Objective: The primary aim of this research was to determine the measurements of spinal components in the Congolese population in order to establish references suitable for local clinical practice. Materials and Methods: Congolese individuals, free from any spinal disorders, participated in a study on vertebral and disc morphology of the lumbar spine after providing informed consent. They underwent computed tomography examinations at medical imaging centers in Brazzaville. The parameters studied included: in axial sections, the transverse diameter (TDb) and sagittal diameter (SDb) of the vertebral bodies, the pedicular transverse diameter (TDp), and in sagittal reconstructions: the height of the vertebral bodies (Hb) and intervertebral discs (Hd). Results: The sample size consisted of 100 subjects (70 men and 30 women), with an average age of 24.47 ± 3.72 years (18 - 30 years). Cranio-caudally, the TDb, DSb, TDp, and Hd showed increasing values, while Hb values were decreasing. In L1, values for both sexes were: TDb = 39.3 ± 3 mm;DSb = 27.3 ± 2.9 mm;Hb = 26.6 ± 2.1 mm;TDp = 8.2 ± 1.8 mm;in L5: TDb = 50.3 ± 4 mm;DSb = 33.6 ± 2.7 mm;Hb = 25.7 ± 2.2 mm;TDp = 14.8 ± 2.1 mm. The Hd values were 8.1 ± 2.1 mm for L1 - L2 and 11.1 ± 2 mm for L5 - S1. Conclusion: Reconstructive spine surgery and the design of implants depend on disc and vertebral measurements, which vary according to racial groups and geographic areas. This variability underscores the importance of studying the morphometric characteristics specific to each population.
基金Supported by the grant of the National Natural Sciences Foundation of China(30470512)
文摘Objective To investigate cerebral structural signatures of the bulbar-and spinal-onset amyotrophic lateral sclerosis(ALS) using voxel-based morphometry on magnetic resonance imaging.Methods The MR structural images of the brain were obtained from 65 ALS patients(15 bulbar-onset, 50 spinalonset) and 65 normal controls(NC) on a 3.0 T MRI system. Gray matter(GM) volume changes were investigated by voxel-based morphometry, and the distribution of the brain regions with volume changes was compared between ALS and normal controls, as well as between bulbar-onset and spinal-onset ALS based on Neuromorphometrics atlas.Results On voxel-level the decreased volume of brain regions in ALS patients was located in the right precentral gyrus(r Prc Gy) and right middle frontal gyrus compared with that in NC. The bulbar-onset ALS presented extramotor cortex atrophy(fronto-temporal pattern), including left medial orbital gyrus, left inferior temporal gyrus and right middle temporal gyrus; the spinal-onset ALS suffered from motor cortex atrophy(r Prc Gy dominance) and extra-motor cortex atrophy(fronto-temporal and extra-fronto-temporal pattern) compared with NC. The spinal-onset ALS featured by GM volume loss of left postcentral gyrus and bulbar-onset ALS featured by GM volume loss of left middle temporal gyrus compared with each other. Conclusions The asymmetric GM atrophy of the motor cortex and extra-motor cortex represents the common MRI structural signatures of spinal-onset ALS, and sole extra-motor cortex atrophy represents the structural signatures of bulbar-onset ALS. The present study also demonstrated that the pattern of GM damage is likely to distribute wider in spinal-onset ALS than in bulbar-onset ALS.
基金Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2023ZL460Zhejiang Province Traditional Chinese Medicine Modernization Special Project,No.2021ZX011。
文摘BACKGROUND Mild cognitive impairment(MCI)is a transitional state between normal aging and Alzheimer's disease(AD),characterized by subtle cognitive decline.Amnestic MCI(aMCI),in particular,is a critical precursor often progressing to AD.There is growing interest in understanding the neuroanatomical correlates of aMCI,especially the role of gray matter volume(GMV)in cognitive and motor function decline.This study hypothesized that aMCI patients will exhibit reduced GMV,particularly in brain regions associated with cognition and motor control,impacting both cognitive performance and motor abilities.AIM To investigate the association of GMV with cognitive and motor functions in aMCI.METHODS In this cross-sectional study conducted from March 2022 to March 2024,45 aMCI patients and 45 normal controls from our Department of Geratology were enrolled.Voxel-based morphometry was used to compare GMV between groups.Correlation of differential GMV with cognitive scores and gait parameters was assessed via partial correlation analysis.Linear regression was used to assess associations between whole-brain GMV and gait measures.RESULTS GMV of aMCI region of interest(ROI)1 and ROI2 was negatively correlated with Activities of Daily Living(ADL)score.GMV of ROI6 was positively correlated with the total scores of Mini-Mental State Examination and Cambridge Cognitive Examination-Chinese Version(CAMCOG-C)and negatively correlated with ADL score.In the partial correlation analysis of cognitive and motor function parameters,age,gender,educational level,height,and weight were controlled,and the results showed that CAMCOG-C was negatively correlated with Dual Task of Time Up and Go Test(TUG)duration in the aMCI group.The volume of the left occipital gray matter in the aMCI group was negatively correlated with TUG.GMV of the bilateral frontal gyrus,right orbitofrontal gyrus,right occipital cleft,right supraoccipital gyrus,and left anterior central gyrus was positively correlated with walking speed.CONCLUSION GMV reduction in aMCI correlates with impaired cognition and motor function,emphasizing key roles for prefrontal,occipital,and central regions in gait disorders.
基金the National Natural Scientific Foundation of China(82071994,82202249)Tianjin Health High Level Talent Selection and Training Project(TJSQNYXXR-D2-143)+4 种基金Natural Scientific Foundation of Tianjin(21CYBJC01580,21JCQNJC01480)Tianjin Health Research Project(TJWJ2023QN031,TJWJ2023XK012)Tianjin Health Science and technology project(Specific projects of key disciplines)(TJWJ2022XK019)Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-041A)Tianjin Natural Science Foundation(21JCYBJC01290).
文摘Hepatic encephalopathy(HE)is a neurological condition that occurs as a complication of liver dysfunction that involves sensorimotor symptoms in addition to cognitive and behavioral changes,particularly in cases of severe liver disease or cirrhosis.Previous studies have reported spatially distributed structural and functional abnormalities related to HE,but the exact relationship between the structural and functional alterations with respect to disease progression remains unclear.In this study,we performed surface-based cortical thickness comparisons and functional connectivity(FC)analyses between three cross-sectional groups:healthy controls(HC,N¼51),patients with minimal hepatic en-cephalopathy(MHE,N¼50),patients with overt hepatic encephalopathy(OHE,N¼51).In addition to the distributed cortical thinning that is extensively thought to be associated with cognitive decline in HE,we found significant cortical thickening in the left para-hippocampal gyrus cortex in the OHE group(p<0.001,p¼0.009)as compared to the HC and MHE group respectively,which is further corroborated by the significant correlation between the cortical thickness and digit symbol test(DST)scores.Furthermore,the decreased FC between the right postcentral gyrus and several sensory regions(bilateral somatosensory and visual cortices)was found to be significant in MHE patients as compared to the HC group.Our results revealed cross-sectional structural and functional variations concerning disease progression across different subsystems(e.g.,visual,motor and sensory),providing evidence that can potentially explain the mechanisms underlying the sensorimotor and cognitive deficits related to HE.
基金supported by Tianjin Key Medical Discipline(Specialty)Construction Project(grant number TJYXZDXK-004A).
文摘Background:Subcortical ischemic vascular dementia(SIVD)is a common subtype of vascular dementia.Currently,the bilateral common carotid artery stenosis(BCAS)mouse model is the most suitable SIVD rodent model.In this study,we investigated the functional and structural impairments in the hippocampus 1 month after BCAS.Methods:We used behavioral tests,laser speckle flowmetry,long-term potentiation,histochemical staining,molecular experiments,and voxel-based morphometry to evaluate the hippocampal impairments.Results:Behavioral studies revealed that BCAS mice exhibited worse performance.Laser speckle flowmetry detected an obvious decrease in cerebral blood flow.The synaptic plasticity of the perforant path-dentate gyrus pathway was inhibited.Decreased fractional anisotropy and increased mean diffusivity were detected in the hippocampus via diffusion tensor imaging data.A reduction in gray matter volume,which was most prominent in the hippocampus and its surrounding areas,was de-tected via voxel-based morphometry analysis.Impairments in cell morphology and myelin integrity were validated using histochemical staining and molecular biology techniques.In addition,the numbers of GFAP+astrocytes and Iba1+microglia in-creased in the hippocampus.Conclusions:Overall,our study demonstrates early functional and structural impair-ments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS,indicating that the hippocampus is vulnerable to chronic cerebral ischemia.
