摘要
目的应用基于体素的形态学测量方法(VBM)观察非神经精神性狼疮患者(non-NPSLE)脑灰质结构变化情况,探索其与认知功能障碍之间的相关性。方法纳入non-NPSLE患者36例(non-NPSLE组)和年龄、性别相匹配的43例健康对照组(HC组)进行3D-T1WI脑结构像扫描,应用VBM分析两组间全脑灰质体积变化,并将组间全脑灰质体积差异结果与MOCA评分进行相关性分析。结果non-NPSLE组右侧颞中下回、左侧内侧眶额皮层、右侧脑岛及双侧海马灰质体积均低于健康对照组(P<0.05,FWE校正),且右侧颞中下回、左侧内侧眶额皮层、右侧脑岛及左侧海马灰质体积与MOCA评分呈正相关(r=0.503、r=0.513、r=0.362、r=0.534、r=0.367,P均<0.05)。结论non-NPSLE患者多个脑区灰质体积减低,且局部脑区灰质体积与MOCA评分呈正相关,提示特异脑区萎缩可能是non-NPSLE患者发生轻度认知障碍的基础。
Objective Voxel-based morphometry(VBM)was used to observe the changes of gray matter structure in patients with non-neuropsychiatric systemic lupus erythematosus(non-NPSLE)and to explore the correlation between gray matter structure and cognitive dysfunction.Methods Thirty-six patients with non-NPSLE(non-NPSLE group)and forty-three healthy controls matched for age and sex(HC group)underwent 3D-T1WI structural brain imaging.VBM was used to analyze the changes of whole brain gray matter volume between the two groups,and the correlation between the results of whole brain gray matter volume differences between the two groups and MOCA scores was analyzed.Results The gray matter volumes of the right middle and inferior temporal gyrus,left medial orbitofrontal cortex,right insula,and bilateral hippocampus in the non-NPSLE group were lower than those in the healthy control group(P<0.05,FWE corrected),and the gray matter volumes of the right middle and inferior temporal gyrus,left medial orbitofrontal cortex,right insula,and left hippocampus were positively correlated with MOCA scores(r=0.503,r=0.513,r=0.362,r=0.534,r=0.367,P<0.05).Conclusion In non-NPSLE patients,gray matter volume decreased in multiple brain regions,and gray matter volume in local brain regions was positively correlated with MOCA score,suggesting that specific brain atrophy may be the basis of mild cognitive impairment in non-NPSLE patients.
作者
李丽
徐成
LI Li;XU Cheng(School of Medical Imaging,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of MRI,The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,Shanxi Province,China)
出处
《中国CT和MRI杂志》
2025年第7期17-19,38,共4页
Chinese Journal of CT and MRI
关键词
非神经精神性狼疮
系统性红斑狼疮
基于体素的形态学测量方法
认知功能
Non-neuropsychiatric Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
Voxel-based Morphometry
Cognitive Function
