目的基于文献计量学总结国内外仿制药领域的研究现状及趋势,为进一步研究提供参考。方法通过检索收集中国学术期刊全文数据库(CNKI)、Web of Science数据库中收录的相关文献,借助CiteSpace6.3R2、VOSview1.6.20、文献计量学在线分析平...目的基于文献计量学总结国内外仿制药领域的研究现状及趋势,为进一步研究提供参考。方法通过检索收集中国学术期刊全文数据库(CNKI)、Web of Science数据库中收录的相关文献,借助CiteSpace6.3R2、VOSview1.6.20、文献计量学在线分析平台等探讨本领域的作者机构合作、国家合作概况,并分析关键词共现、聚类、突现等,并对分析结果可视化展示。结果共纳入2564篇文献,其中中文文献641篇,英文文献1923篇。刊文趋势表明,国内外仿制药领域研究的发展趋势基本相同。目前本领域研究已有国际化趋势,但我国的国际合作中心性为0。关键词分析显示,国内外仿制药领域研究内容在保持一致的前提下各有侧重,其研究内容与热点可相互补充借鉴。结论系统分析了2000—2024年间仿制药领域的相关文献,总结了目前全球仿制药领域的研究现状及趋势,并进一步指出国内外研究的异同,可为本领域的进一步研究提供指导。展开更多
地热作为绿色低碳的可再生能源,在能源领域具有重要意义。为了探究当前国内外学者在地热领域的研究方向和热点,明确地热研究的发展前景,对2000—2023年中国知网(CNKI)和Web of Science(WoS)数据库所收录的地热领域高质量文献进行检索,...地热作为绿色低碳的可再生能源,在能源领域具有重要意义。为了探究当前国内外学者在地热领域的研究方向和热点,明确地热研究的发展前景,对2000—2023年中国知网(CNKI)和Web of Science(WoS)数据库所收录的地热领域高质量文献进行检索,并利用VOS viewer进行可视化分析,掌握数据库年发文量、国家和机构、期刊发文量、高被引文献及文献所涉及的关键词。研究结果表明,在2000—2023年间,地热研究方向中英文文献的发文量总体均呈上升趋势;在发文机构方面,中国地质大学、中国科学院等中国科研机构已跃升为发文的重要基石,主要发表在《水文地质工程地质》《Geothermics》《太阳能学报》《Geothermics》的文献最多,为1213篇;地热领域研究主要集中于地热资源勘探与开发。研究可为科研人员全面了解2000年至今的地热研究现状与未来发展趋势提供参考。展开更多
A pseudocapacitance dominated anode material assembled from Li_(3)VO_(4)nanocrystals encapsulated in the interlayers of N-doped graphene has been developed via a facile 2D nanospace confined strategy for lithium ion c...A pseudocapacitance dominated anode material assembled from Li_(3)VO_(4)nanocrystals encapsulated in the interlayers of N-doped graphene has been developed via a facile 2D nanospace confined strategy for lithium ion capacitors(LICs).In this contribution,the N-doped graphene synthesized by a faicle solid state reaction using C_(3)N_(4)nanosheets as template and glucose as carbon source provides sufficient 2D nanospace for the confined and homogeneous growth of Li_(3)VO_(4)at the nanoscale,and simultaneously efficiently anchors each nanobuilding block inside the interlayers,thus realizing the utilizaiton of full potential of active components.The so-formed 3D hybrids not only ensure intimate electronic coupling between active materials and N-doped graphene,but also realize robust structure integrity.Owing to these unique advantages,the resulting hybrids show pseudocapacitance dominated lithium storage behaviors with capacitive contributions of over 90%at both low and high current rates.The LVO@C@NG delivers reversible capacities of 206 mAh/g at 10 A/g,capacity retention of 92.7%after 1000 cycles at 2 A/g,and a high energy density of 113.6 Wh/kg at 231.8 W/kg for LICs.展开更多
目的基于VOSviewer软件可视化分析肾癌靶向治疗的研究现状、热点和前沿。方法从Web of Science(WOS)核心合集数据库中检索2006年1月1日—2023年12月31日发表的有关肾癌靶向治疗的文献,筛选出符合标准的文献,通过VOSviewer软件对文献进...目的基于VOSviewer软件可视化分析肾癌靶向治疗的研究现状、热点和前沿。方法从Web of Science(WOS)核心合集数据库中检索2006年1月1日—2023年12月31日发表的有关肾癌靶向治疗的文献,筛选出符合标准的文献,通过VOSviewer软件对文献进行计量分析和可视化分析。结果筛选后共获得1009篇文献,年发文量总体呈上升趋势;发文量排名前3位的国家依次是美国、中国和意大利,发文量排名前3位的机构依次是哈佛大学、得克萨斯大学和法国综合癌症中心。核心作者合作网络分析结果显示,美国和英国的研究人员在该领域的合作较为紧密,而中国与国外的合作较少,合作网络比较松散。选取高频作者关键词进行共现聚类分析,共生成9个聚类,热点主要集中于靶向与免疫联合治疗、疗效、预后、耐药性、靶点及生物标志物等方面。结论近十几年来,肾癌的靶向治疗研究取得显著进展,然而,靶向药物的耐药性和不良反应仍然是临床治疗中的难点。针对靶向药物耐药机制、新型靶向药物及有效预测生物标志物的相关研究显著增加。掌握该领域的发展趋势至关重要,VOSviewer可视化分析可展现该领域的现状、热点及前沿,为研究者提供直观的参考依据。展开更多
目的 基于文献分析癌性疼痛(癌痛)药物研究热点和趋势。方法 检索在中国知网(CNKI)和Web of Science数据库发表的癌痛与药物相关研究文献,采用VOS-viewer 1.6.18版和CiteSpace 6.2.R3版软件对所纳入文献绘制图谱,对发文量、期刊、机构...目的 基于文献分析癌性疼痛(癌痛)药物研究热点和趋势。方法 检索在中国知网(CNKI)和Web of Science数据库发表的癌痛与药物相关研究文献,采用VOS-viewer 1.6.18版和CiteSpace 6.2.R3版软件对所纳入文献绘制图谱,对发文量、期刊、机构、作者和关键词进行分析。结果 共纳入文献4 774篇,发文量最多的期刊是《中国疼痛医学杂志》和《Journal of Pain and Symptom Management》;发文量最多的作者是刘端祺和Bruera Eduardo;发文量最高的机构为华中科技大学同济医学院附属同济医院和University of Texas Anderson Cancercenter;出现频次最高的关键词为癌痛;最新的突现词主要是临床疗效、日均费用和初级护理等。结论 进入21世纪,癌痛药物研究逐步升温,发文量呈上升趋势;2019-2022年,癌痛药物的研究国内外主要集中在癌痛药物的临床疗效、日均费用等方面。该文在一定程度上明确了癌痛药物近年来的研究热点,对今后的研究有一定参考意义。展开更多
Cardiorespiratory fitness (CRF) is considered a foundation for good health and longevity. The variable, VO2max, is considered a reliable measure of cardiorespiratory health. The measurement of VO2max is stressful and ...Cardiorespiratory fitness (CRF) is considered a foundation for good health and longevity. The variable, VO2max, is considered a reliable measure of cardiorespiratory health. The measurement of VO2max is stressful and is not a common practice, thus, it is desirable to relate VO2max to other variables including age, gender, Body Mass Index (BMI), body fat percentage (BFP), and physical activity. Mathematical models are presented to relate VO2max to age, gender, BMI, body fat percentage, and aerobic exercise. Predictions match well with measured VO2max data published in the literature. The robust models are stable for all boundary conditions including young adults to old age and lower sedentary to Olympic-trained levels of relative fitness for both male and female applications. The relationship may be especially helpful for older people who are dealing with elevated values of BMI. The models build on two levels of relative fitness (sedentary and endurance-trained) and boundary conditions of Olympic-trained athletes and lower sedentary conditions. Thus, the model responds to a full range of fitness conditions. Four equations are provided: one with relative fitness related to distance walked or ran each week, one using BMI to estimate relative fitness, and two using both BMI and BFP to estimate relative fitness (one interacting with age). An equation is also provided to evaluate the dynamic change in relative fitness using input of distance walked or ran each day, which can be estimated by a smart watch. The equation that only uses age, gender, and BMI as inputs overestimates VO2max for people with low BMI and who are physically inactive. This weakness is partially overcome by adding BFP as a variable when available. The most accurate equation is the one that uses distance walked or ran each day to estimate relative fitness based on the individual’s physical activity. Unfortunately, this method requires the individual to keep track of their physical activity daily. Relative fitness may be a more appropriate variable than VO2max to indicate fitness because it is independent of age.展开更多
文摘目的基于文献计量学总结国内外仿制药领域的研究现状及趋势,为进一步研究提供参考。方法通过检索收集中国学术期刊全文数据库(CNKI)、Web of Science数据库中收录的相关文献,借助CiteSpace6.3R2、VOSview1.6.20、文献计量学在线分析平台等探讨本领域的作者机构合作、国家合作概况,并分析关键词共现、聚类、突现等,并对分析结果可视化展示。结果共纳入2564篇文献,其中中文文献641篇,英文文献1923篇。刊文趋势表明,国内外仿制药领域研究的发展趋势基本相同。目前本领域研究已有国际化趋势,但我国的国际合作中心性为0。关键词分析显示,国内外仿制药领域研究内容在保持一致的前提下各有侧重,其研究内容与热点可相互补充借鉴。结论系统分析了2000—2024年间仿制药领域的相关文献,总结了目前全球仿制药领域的研究现状及趋势,并进一步指出国内外研究的异同,可为本领域的进一步研究提供指导。
文摘地热作为绿色低碳的可再生能源,在能源领域具有重要意义。为了探究当前国内外学者在地热领域的研究方向和热点,明确地热研究的发展前景,对2000—2023年中国知网(CNKI)和Web of Science(WoS)数据库所收录的地热领域高质量文献进行检索,并利用VOS viewer进行可视化分析,掌握数据库年发文量、国家和机构、期刊发文量、高被引文献及文献所涉及的关键词。研究结果表明,在2000—2023年间,地热研究方向中英文文献的发文量总体均呈上升趋势;在发文机构方面,中国地质大学、中国科学院等中国科研机构已跃升为发文的重要基石,主要发表在《水文地质工程地质》《Geothermics》《太阳能学报》《Geothermics》的文献最多,为1213篇;地热领域研究主要集中于地热资源勘探与开发。研究可为科研人员全面了解2000年至今的地热研究现状与未来发展趋势提供参考。
基金financially supported by the National Natural Science Foundation of China(Nos.52001059,52072119)Hunan Provincial Natural Science Foundation(No.2023JJ50015)the 111 Project(No.D20015)。
文摘A pseudocapacitance dominated anode material assembled from Li_(3)VO_(4)nanocrystals encapsulated in the interlayers of N-doped graphene has been developed via a facile 2D nanospace confined strategy for lithium ion capacitors(LICs).In this contribution,the N-doped graphene synthesized by a faicle solid state reaction using C_(3)N_(4)nanosheets as template and glucose as carbon source provides sufficient 2D nanospace for the confined and homogeneous growth of Li_(3)VO_(4)at the nanoscale,and simultaneously efficiently anchors each nanobuilding block inside the interlayers,thus realizing the utilizaiton of full potential of active components.The so-formed 3D hybrids not only ensure intimate electronic coupling between active materials and N-doped graphene,but also realize robust structure integrity.Owing to these unique advantages,the resulting hybrids show pseudocapacitance dominated lithium storage behaviors with capacitive contributions of over 90%at both low and high current rates.The LVO@C@NG delivers reversible capacities of 206 mAh/g at 10 A/g,capacity retention of 92.7%after 1000 cycles at 2 A/g,and a high energy density of 113.6 Wh/kg at 231.8 W/kg for LICs.
文摘目的基于VOSviewer软件可视化分析肾癌靶向治疗的研究现状、热点和前沿。方法从Web of Science(WOS)核心合集数据库中检索2006年1月1日—2023年12月31日发表的有关肾癌靶向治疗的文献,筛选出符合标准的文献,通过VOSviewer软件对文献进行计量分析和可视化分析。结果筛选后共获得1009篇文献,年发文量总体呈上升趋势;发文量排名前3位的国家依次是美国、中国和意大利,发文量排名前3位的机构依次是哈佛大学、得克萨斯大学和法国综合癌症中心。核心作者合作网络分析结果显示,美国和英国的研究人员在该领域的合作较为紧密,而中国与国外的合作较少,合作网络比较松散。选取高频作者关键词进行共现聚类分析,共生成9个聚类,热点主要集中于靶向与免疫联合治疗、疗效、预后、耐药性、靶点及生物标志物等方面。结论近十几年来,肾癌的靶向治疗研究取得显著进展,然而,靶向药物的耐药性和不良反应仍然是临床治疗中的难点。针对靶向药物耐药机制、新型靶向药物及有效预测生物标志物的相关研究显著增加。掌握该领域的发展趋势至关重要,VOSviewer可视化分析可展现该领域的现状、热点及前沿,为研究者提供直观的参考依据。
文摘目的 基于文献分析癌性疼痛(癌痛)药物研究热点和趋势。方法 检索在中国知网(CNKI)和Web of Science数据库发表的癌痛与药物相关研究文献,采用VOS-viewer 1.6.18版和CiteSpace 6.2.R3版软件对所纳入文献绘制图谱,对发文量、期刊、机构、作者和关键词进行分析。结果 共纳入文献4 774篇,发文量最多的期刊是《中国疼痛医学杂志》和《Journal of Pain and Symptom Management》;发文量最多的作者是刘端祺和Bruera Eduardo;发文量最高的机构为华中科技大学同济医学院附属同济医院和University of Texas Anderson Cancercenter;出现频次最高的关键词为癌痛;最新的突现词主要是临床疗效、日均费用和初级护理等。结论 进入21世纪,癌痛药物研究逐步升温,发文量呈上升趋势;2019-2022年,癌痛药物的研究国内外主要集中在癌痛药物的临床疗效、日均费用等方面。该文在一定程度上明确了癌痛药物近年来的研究热点,对今后的研究有一定参考意义。
文摘Cardiorespiratory fitness (CRF) is considered a foundation for good health and longevity. The variable, VO2max, is considered a reliable measure of cardiorespiratory health. The measurement of VO2max is stressful and is not a common practice, thus, it is desirable to relate VO2max to other variables including age, gender, Body Mass Index (BMI), body fat percentage (BFP), and physical activity. Mathematical models are presented to relate VO2max to age, gender, BMI, body fat percentage, and aerobic exercise. Predictions match well with measured VO2max data published in the literature. The robust models are stable for all boundary conditions including young adults to old age and lower sedentary to Olympic-trained levels of relative fitness for both male and female applications. The relationship may be especially helpful for older people who are dealing with elevated values of BMI. The models build on two levels of relative fitness (sedentary and endurance-trained) and boundary conditions of Olympic-trained athletes and lower sedentary conditions. Thus, the model responds to a full range of fitness conditions. Four equations are provided: one with relative fitness related to distance walked or ran each week, one using BMI to estimate relative fitness, and two using both BMI and BFP to estimate relative fitness (one interacting with age). An equation is also provided to evaluate the dynamic change in relative fitness using input of distance walked or ran each day, which can be estimated by a smart watch. The equation that only uses age, gender, and BMI as inputs overestimates VO2max for people with low BMI and who are physically inactive. This weakness is partially overcome by adding BFP as a variable when available. The most accurate equation is the one that uses distance walked or ran each day to estimate relative fitness based on the individual’s physical activity. Unfortunately, this method requires the individual to keep track of their physical activity daily. Relative fitness may be a more appropriate variable than VO2max to indicate fitness because it is independent of age.
