Objective: to analyze the effect of compound lactobacillus acidophilus tablet combined with omeprazole enteric-coated tablet on disease control in patients with acute gastroenteritis. Methods: patients with acute gast...Objective: to analyze the effect of compound lactobacillus acidophilus tablet combined with omeprazole enteric-coated tablet on disease control in patients with acute gastroenteritis. Methods: patients with acute gastroenteritis were selected as the subjects of the study, and the patients admitted from June 2019 to August 2020 were selected for the period of time. The patients were divided into two groups by random number method for comparative exploration, and the changes of the condition of 100 patients were recorded. The control group was given compound lactobacillus acidophilus tablet, and the observation group was given compound Lactobacillus acidophilus tablet combined with omeprazole enteric-coated tablet. The therapeutic effect was analyzed. Results: from the quality of treatment, the treatment effect of observation group was 90%, the control group was 78%, the difference between the groups was significant, with statistical significance (P < 0.05). At the same time, the incidence of adverse events in the observation group was 4% (2/50), significantly lower than that in the control group (10%, 5/50), and the difference was statistically significant. Conclusion: the combination of compound Lactobacillus acidophilus tablets and omeprazole enteric-coated tablets in the treatment of acute gastroenteritis can not only manage the disease and improve the therapeutic effect, but also have high safety guarantee and clinical promotion value.展开更多
Omeprazole is a potent proton pump inhibitor with powerful inhibition of secretion of gastric juice. Oral site-specific drug delivery systems have recently attracted a great interest for the local treatment of bowel d...Omeprazole is a potent proton pump inhibitor with powerful inhibition of secretion of gastric juice. Oral site-specific drug delivery systems have recently attracted a great interest for the local treatment of bowel disease and for improving systemic absorption of drugs which are unstable in the stomach. However, microenvironment in the gastrointestinal tract and varying absorption mechanisms cause hindrance for the formulation and optimization of oral drug delivery. The objective of the study was to develop and optimize enteric coating process for omeprazole tablets. Different batches of core tablets were sub coated, one set sub coated with opadry and another with a mixture of light magnesium oxide, magnesium stearate and absolute alcohol omeprazole magnesium. Seal coating was applied by using opadry to achieve certain weight gain and to protect omeprazole from acidic coating polymers. A comparative dissolution test was performed. The variation of thickness and diameter were observed to be minimal with a weight gain of 3% - 4% of enteric polymer. Disintegration test showed that in each tested batch the enteric coated layer remained intact in 0.1N HCl for 2 hours and when exposed to alkaline media of phosphate buffer pH 6.8, it dissolved within few minutes. Dissolution release was 98.8% to 102.4% within two hours when the product was exposed to phosphate buffer pH 6.8 after 2 hours. The similarity and dis-similarity factors were calculated and observed to be 54 to 61 and 4 to 5 respectively. Therefore a simple and good enteric coating process was developed and tested with potential for transfer this technology into local pharmaceutical industries using cheap and easily available materials.展开更多
Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were sele...Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.展开更多
Objective: to explore the clinical value of rebeprazole and omeprazole in gastric ulcer. Methods: patients with gastric ulcer were recorded in this experiment. Experiments began in July 2010 and ended in July 2021.A t...Objective: to explore the clinical value of rebeprazole and omeprazole in gastric ulcer. Methods: patients with gastric ulcer were recorded in this experiment. Experiments began in July 2010 and ended in July 2021.A total of 94 patients, equally divided to different groups, were based on the lottery method. Reference group: 47 patients were treated together with omeprazole, clarithromycin, amoxicillin, and colloidal pectin, bismuth. Test group: rebeprazole sodium enteric-coated tablets, clarithromycin, amoxicillin, colloidal pectin and bismuth therapy. Observation index: Improvement of clinical symptoms score of group 2 gastric ulcer patients, improvement of gastrointestinal hormone level, improvement of ulcer area and pain score;and occurrence of adverse reactions. Results: (1) Before treatment, the difference of clinical symptoms was weak, with P-value was 0.05.After treatment, the points of stomach pain, abdominal distension, acid reflux and poor appetite were decreased, and the test group had lower points, and the P-value was less than 0.05. (2) Before the treatment, the distribution of gastrointestinal hormone levels was relatively balanced, with a large P-value ratio of 0.05.After treatment, gastrin level and motility level decreased in each group, and the test group had lower data with a P value less than 0.05. (3) Before treatment, the ulcer area and pain score were similar, with a large P-value ratio of 0.05.After treatment, the ulcer area and pain score in each group showed a downward trend, and the value of the test group was smaller, and the P-value was less than 0.05. (4) In The reference group, the probability of adverse reactions such as gastric spasm, nausea and dizziness was higher than that of the test group, and the P-value was less than 0.05. Conclusion: based on the treatment of gastric ulcer.The improvement of symptom integral and the improvement of gastrointestinal hormone level were more obvious, and the ulcer area was reduced, and the pain was relieved.展开更多
Objective: to investigate the clinical effect of compound Lactobacillus acidophilus tablets and omeprazole enteric coated tablets combined with compound Lactobacillus acidophilus tablets in patients with acute gastroe...Objective: to investigate the clinical effect of compound Lactobacillus acidophilus tablets and omeprazole enteric coated tablets combined with compound Lactobacillus acidophilus tablets in patients with acute gastroenteritis. Methods: the period from May 2018 to May 2020 was selected as the research period and 106 patients with acute gastroenteritis in our hospital during this period were selected for study. All the patients were randomly divided into control group and treatment group, 53 cases in each group. The control group was given compound Lactobacillus acidophilus tablets and the treatment group was given compound Lactobacillus acidophilus tablets combined with omeprazole enteric coated tablets. After 2 weeks of continuous treatment, the improvement of clinical symptoms and the overall curative effect were compared between the two groups. Results: compared with the control group, the clinical symptom score of the treatment group was lower (P < 0.05), and the overall efficacy was higher (P < 0.05). Conclusion: Omeprazole enteric coated tablets combined with compound Lactobacillus acidophilus tablets in the treatment of acute gastroenteritis can effectively relieve symptoms and acute inflammatory reaction, with definite curative effect and good feasible value.展开更多
Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from Janu...Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from January 2020 to December 2023,the sample source was 82 AMI patients admitted to our hospital,grouped into an observation group(n=41)and a control group(n=41)by the numerical table method.The patients in the control group were treated with aspirin enteric-coated tablets,and the patients in the observation group were treated with aspirin enteric-coated tablets combined with clopidogrel bisulfate.The clinical efficacy,coagulation indexes,and the incidence of cardiovascular adverse events between the two groups were compared.Results:The clinical efficacy of the observation group was higher than that of the control group(P<0.05);the platelet aggregation rate(PAR)of the observation group was lower than that of the con-trol group after treatment(P<0.05),and there was no significant difference in the prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).The incidence of cardiovascular adverse events in the observation group was lower than that of the control group(P<0.05).Conclusion:The treatment effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on AMI patients is remarkable.It reduces the PAR and the incidence of cardiovascular adverse events,so this treatment method should be popularized.展开更多
Objective: to study the therapeutic effect of mesalazine enteric-coated tablet combined with bifidobacterium triple viable capsule in the treatment of ulcerative colitis. Methods: the therapeutic effect of mesalazine ...Objective: to study the therapeutic effect of mesalazine enteric-coated tablet combined with bifidobacterium triple viable capsule in the treatment of ulcerative colitis. Methods: the therapeutic effect of mesalazine enteric-coated tablets combined with bifidum triple viable capsule was analyzed in 100 patients with ulcerative colitis from January 2020 to July 2021. Results: the experimental group (χ2=6.5236, P=0.0234) had higher curative effect (P < 0.05). Adverse reactions (χ2=4.5236, P=0.0011) were lower,P < 0.05. IL-6 (t=8.5241, P=0.0000) and TNF-α (t=10.2531, P=0.0000) were lower, P < 0.05. D-lactic acid (t5.2362 =,P=0.0000) and botulinum toxin (t=12.5246, P=0.0000) were lower (P < 0.05). Conclusion: mesalazine enteric-coated tablet combined with bifidum triple living capsule is effective and safe.展开更多
A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was car...A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5%for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD%for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.展开更多
BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they ma...BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential.展开更多
文摘Objective: to analyze the effect of compound lactobacillus acidophilus tablet combined with omeprazole enteric-coated tablet on disease control in patients with acute gastroenteritis. Methods: patients with acute gastroenteritis were selected as the subjects of the study, and the patients admitted from June 2019 to August 2020 were selected for the period of time. The patients were divided into two groups by random number method for comparative exploration, and the changes of the condition of 100 patients were recorded. The control group was given compound lactobacillus acidophilus tablet, and the observation group was given compound Lactobacillus acidophilus tablet combined with omeprazole enteric-coated tablet. The therapeutic effect was analyzed. Results: from the quality of treatment, the treatment effect of observation group was 90%, the control group was 78%, the difference between the groups was significant, with statistical significance (P < 0.05). At the same time, the incidence of adverse events in the observation group was 4% (2/50), significantly lower than that in the control group (10%, 5/50), and the difference was statistically significant. Conclusion: the combination of compound Lactobacillus acidophilus tablets and omeprazole enteric-coated tablets in the treatment of acute gastroenteritis can not only manage the disease and improve the therapeutic effect, but also have high safety guarantee and clinical promotion value.
文摘Omeprazole is a potent proton pump inhibitor with powerful inhibition of secretion of gastric juice. Oral site-specific drug delivery systems have recently attracted a great interest for the local treatment of bowel disease and for improving systemic absorption of drugs which are unstable in the stomach. However, microenvironment in the gastrointestinal tract and varying absorption mechanisms cause hindrance for the formulation and optimization of oral drug delivery. The objective of the study was to develop and optimize enteric coating process for omeprazole tablets. Different batches of core tablets were sub coated, one set sub coated with opadry and another with a mixture of light magnesium oxide, magnesium stearate and absolute alcohol omeprazole magnesium. Seal coating was applied by using opadry to achieve certain weight gain and to protect omeprazole from acidic coating polymers. A comparative dissolution test was performed. The variation of thickness and diameter were observed to be minimal with a weight gain of 3% - 4% of enteric polymer. Disintegration test showed that in each tested batch the enteric coated layer remained intact in 0.1N HCl for 2 hours and when exposed to alkaline media of phosphate buffer pH 6.8, it dissolved within few minutes. Dissolution release was 98.8% to 102.4% within two hours when the product was exposed to phosphate buffer pH 6.8 after 2 hours. The similarity and dis-similarity factors were calculated and observed to be 54 to 61 and 4 to 5 respectively. Therefore a simple and good enteric coating process was developed and tested with potential for transfer this technology into local pharmaceutical industries using cheap and easily available materials.
文摘Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.
文摘Objective: to explore the clinical value of rebeprazole and omeprazole in gastric ulcer. Methods: patients with gastric ulcer were recorded in this experiment. Experiments began in July 2010 and ended in July 2021.A total of 94 patients, equally divided to different groups, were based on the lottery method. Reference group: 47 patients were treated together with omeprazole, clarithromycin, amoxicillin, and colloidal pectin, bismuth. Test group: rebeprazole sodium enteric-coated tablets, clarithromycin, amoxicillin, colloidal pectin and bismuth therapy. Observation index: Improvement of clinical symptoms score of group 2 gastric ulcer patients, improvement of gastrointestinal hormone level, improvement of ulcer area and pain score;and occurrence of adverse reactions. Results: (1) Before treatment, the difference of clinical symptoms was weak, with P-value was 0.05.After treatment, the points of stomach pain, abdominal distension, acid reflux and poor appetite were decreased, and the test group had lower points, and the P-value was less than 0.05. (2) Before the treatment, the distribution of gastrointestinal hormone levels was relatively balanced, with a large P-value ratio of 0.05.After treatment, gastrin level and motility level decreased in each group, and the test group had lower data with a P value less than 0.05. (3) Before treatment, the ulcer area and pain score were similar, with a large P-value ratio of 0.05.After treatment, the ulcer area and pain score in each group showed a downward trend, and the value of the test group was smaller, and the P-value was less than 0.05. (4) In The reference group, the probability of adverse reactions such as gastric spasm, nausea and dizziness was higher than that of the test group, and the P-value was less than 0.05. Conclusion: based on the treatment of gastric ulcer.The improvement of symptom integral and the improvement of gastrointestinal hormone level were more obvious, and the ulcer area was reduced, and the pain was relieved.
文摘Objective: to investigate the clinical effect of compound Lactobacillus acidophilus tablets and omeprazole enteric coated tablets combined with compound Lactobacillus acidophilus tablets in patients with acute gastroenteritis. Methods: the period from May 2018 to May 2020 was selected as the research period and 106 patients with acute gastroenteritis in our hospital during this period were selected for study. All the patients were randomly divided into control group and treatment group, 53 cases in each group. The control group was given compound Lactobacillus acidophilus tablets and the treatment group was given compound Lactobacillus acidophilus tablets combined with omeprazole enteric coated tablets. After 2 weeks of continuous treatment, the improvement of clinical symptoms and the overall curative effect were compared between the two groups. Results: compared with the control group, the clinical symptom score of the treatment group was lower (P < 0.05), and the overall efficacy was higher (P < 0.05). Conclusion: Omeprazole enteric coated tablets combined with compound Lactobacillus acidophilus tablets in the treatment of acute gastroenteritis can effectively relieve symptoms and acute inflammatory reaction, with definite curative effect and good feasible value.
文摘Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from January 2020 to December 2023,the sample source was 82 AMI patients admitted to our hospital,grouped into an observation group(n=41)and a control group(n=41)by the numerical table method.The patients in the control group were treated with aspirin enteric-coated tablets,and the patients in the observation group were treated with aspirin enteric-coated tablets combined with clopidogrel bisulfate.The clinical efficacy,coagulation indexes,and the incidence of cardiovascular adverse events between the two groups were compared.Results:The clinical efficacy of the observation group was higher than that of the control group(P<0.05);the platelet aggregation rate(PAR)of the observation group was lower than that of the con-trol group after treatment(P<0.05),and there was no significant difference in the prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).The incidence of cardiovascular adverse events in the observation group was lower than that of the control group(P<0.05).Conclusion:The treatment effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on AMI patients is remarkable.It reduces the PAR and the incidence of cardiovascular adverse events,so this treatment method should be popularized.
文摘Objective: to study the therapeutic effect of mesalazine enteric-coated tablet combined with bifidobacterium triple viable capsule in the treatment of ulcerative colitis. Methods: the therapeutic effect of mesalazine enteric-coated tablets combined with bifidum triple viable capsule was analyzed in 100 patients with ulcerative colitis from January 2020 to July 2021. Results: the experimental group (χ2=6.5236, P=0.0234) had higher curative effect (P < 0.05). Adverse reactions (χ2=4.5236, P=0.0011) were lower,P < 0.05. IL-6 (t=8.5241, P=0.0000) and TNF-α (t=10.2531, P=0.0000) were lower, P < 0.05. D-lactic acid (t5.2362 =,P=0.0000) and botulinum toxin (t=12.5246, P=0.0000) were lower (P < 0.05). Conclusion: mesalazine enteric-coated tablet combined with bifidum triple living capsule is effective and safe.
文摘A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5%for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD%for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.
文摘BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential.
